Serum Cell Death Biomarkers for Prediction of Liver Fibrosis and Poor Prognosis in Primary Biliary Cirrhosis

Tomohiro Sekiguchi; Takeji Umemura; Naoyuki Fujimori; Soichiro Shibata; Yuki Ichikawa; Takefumi Kimura; Satoru Joshita; Michiharu Komatsu; Akihiro Matsumoto; Eiji Tanaka; Masao Ota

doi:10.1371/journal.pone.0131658

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Open Access

Peer-reviewed

Research Article

Serum Cell Death Biomarkers for Prediction of Liver Fibrosis and Poor Prognosis in Primary Biliary Cirrhosis

Tomohiro Sekiguchi ,

Contributed equally to this work with: Tomohiro Sekiguchi, Takeji Umemura

Affiliation Department of Medicine, Division of Hepatology and Gastroenterology, Shinshu University School of Medicine, Matsumoto, Japan
⨯
Takeji Umemura ,

Contributed equally to this work with: Tomohiro Sekiguchi, Takeji Umemura

* E-mail: tumemura@shinshu-u.ac.jp

Affiliation Department of Medicine, Division of Hepatology and Gastroenterology, Shinshu University School of Medicine, Matsumoto, Japan
⨯
Naoyuki Fujimori,

Affiliation Department of Medicine, Division of Hepatology and Gastroenterology, Shinshu University School of Medicine, Matsumoto, Japan
⨯
Soichiro Shibata,

Affiliation Department of Medicine, Division of Hepatology and Gastroenterology, Shinshu University School of Medicine, Matsumoto, Japan
⨯
Yuki Ichikawa,

Affiliation Department of Medicine, Division of Hepatology and Gastroenterology, Shinshu University School of Medicine, Matsumoto, Japan
⨯
Takefumi Kimura,

Affiliation Department of Medicine, Division of Hepatology and Gastroenterology, Shinshu University School of Medicine, Matsumoto, Japan
⨯
Satoru Joshita,

Affiliation Department of Medicine, Division of Hepatology and Gastroenterology, Shinshu University School of Medicine, Matsumoto, Japan
⨯
Michiharu Komatsu,

Affiliation Department of Medicine, Division of Hepatology and Gastroenterology, Shinshu University School of Medicine, Matsumoto, Japan
⨯
Akihiro Matsumoto,

Affiliation Department of Medicine, Division of Hepatology and Gastroenterology, Shinshu University School of Medicine, Matsumoto, Japan
⨯
Eiji Tanaka,

Affiliation Department of Medicine, Division of Hepatology and Gastroenterology, Shinshu University School of Medicine, Matsumoto, Japan
⨯
Masao Ota

Affiliation Department of Legal Medicine, Shinshu University Hospital, Matsumoto, Japan
⨯

Serum Cell Death Biomarkers for Prediction of Liver Fibrosis and Poor Prognosis in Primary Biliary Cirrhosis

Tomohiro Sekiguchi,
Takeji Umemura,
Naoyuki Fujimori,
Soichiro Shibata,
Yuki Ichikawa,
Takefumi Kimura,
Satoru Joshita,
Michiharu Komatsu,
Akihiro Matsumoto,
Eiji Tanaka

Published: June 25, 2015
https://doi.org/10.1371/journal.pone.0131658

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Fibrosis
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Apoptosis
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Primary biliary cirrhosis
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Biomarkers
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Liver fibrosis
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Biopsy
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Cell death
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Cirrhosis
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