Characterization of SMAD3 Gene Variants for Possible Roles in Ventricular Septal Defects and Other Congenital Heart Diseases

Fei-Feng Li; Jing Zhou; Dan-Dan Zhao; Peng Yan; Xia Li; Ying Han; Xian-Shu Li; Gui-Yu Wang; Kai-Jiang Yu; Shu-Lin Liu

doi:10.1371/journal.pone.0131542

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Open Access

Peer-reviewed

Research Article

Characterization of SMAD3 Gene Variants for Possible Roles in Ventricular Septal Defects and Other Congenital Heart Diseases

Fei-Feng Li ,

Contributed equally to this work with: Fei-Feng Li, Jing Zhou

Affiliation Genomics Research Center (one of the State-Province Key Laboratory of Biopharmaceutical Engineering, China), Harbin Medical University, Harbin, China
⨯
Jing Zhou ,

Contributed equally to this work with: Fei-Feng Li, Jing Zhou

Affiliation Intensive Care Unit, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
⨯
Dan-Dan Zhao,

Affiliation Genomics Research Center (one of the State-Province Key Laboratory of Biopharmaceutical Engineering, China), Harbin Medical University, Harbin, China
⨯
Peng Yan,

Affiliation Department of Colorectal Surgery, the Second Affiliated Hospital of Harbin Medical University, Harbin, China
⨯
Xia Li,

Affiliation Genomics Research Center (one of the State-Province Key Laboratory of Biopharmaceutical Engineering, China), Harbin Medical University, Harbin, China
⨯
Ying Han,

Affiliation Genomics Research Center (one of the State-Province Key Laboratory of Biopharmaceutical Engineering, China), Harbin Medical University, Harbin, China
⨯
Xian-Shu Li,

Affiliation Daqing People’s Hospital, Daqing, China
⨯
Gui-Yu Wang ,

* E-mail: guiywang@gmail.com (GYW); drkaijiang@163.com (KJY); slliu@ucalgary.ca (SLL)

Affiliation Department of Colorectal Surgery, the Second Affiliated Hospital of Harbin Medical University, Harbin, China
⨯
Kai-Jiang Yu ,

* E-mail: guiywang@gmail.com (GYW); drkaijiang@163.com (KJY); slliu@ucalgary.ca (SLL)

Affiliation Intensive Care Unit, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
⨯
Shu-Lin Liu

* E-mail: guiywang@gmail.com (GYW); drkaijiang@163.com (KJY); slliu@ucalgary.ca (SLL)

Affiliations Genomics Research Center (one of the State-Province Key Laboratory of Biopharmaceutical Engineering, China), Harbin Medical University, Harbin, China, Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, Canada
⨯

Characterization of SMAD3 Gene Variants for Possible Roles in Ventricular Septal Defects and Other Congenital Heart Diseases

Fei-Feng Li,
Jing Zhou,
Dan-Dan Zhao,
Peng Yan,
Xia Li,
Ying Han,
Xian-Shu Li,
Gui-Yu Wang,
Kai-Jiang Yu,
Shu-Lin Liu

Published: June 25, 2015
https://doi.org/10.1371/journal.pone.0131542

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Ventricular septal defects
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Single nucleotide polymorphisms
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Congenital heart defects
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Han Chinese people
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Variant genotypes
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