Vitamin D Antagonises the Suppressive Effect of Inflammatory Cytokines on CTLA-4 Expression and Regulatory Function

Louisa E. Jeffery; Omar S. Qureshi; David Gardner; Tie Z. Hou; Zoe Briggs; Blagoje Soskic; Jennifer Baker; Karim Raza; David M. Sansom

doi:10.1371/journal.pone.0131539

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Peer-reviewed

Research Article

Vitamin D Antagonises the Suppressive Effect of Inflammatory Cytokines on CTLA-4 Expression and Regulatory Function

Louisa E. Jeffery,

Affiliation Medical Research Council Centre for Immune Regulation, School of Immunity and Infection, Institute of Biomedical Research, University of Birmingham Medical School, Birmingham, United Kingdom
⨯
Omar S. Qureshi,

Affiliation Medical Research Council Centre for Immune Regulation, School of Immunity and Infection, Institute of Biomedical Research, University of Birmingham Medical School, Birmingham, United Kingdom
⨯
David Gardner,

Affiliation Medical Research Council Centre for Immune Regulation, School of Immunity and Infection, Institute of Biomedical Research, University of Birmingham Medical School, Birmingham, United Kingdom
⨯
Tie Z. Hou,

Affiliation UCL Institute of Immunity and Transplantation, Royal Free Campus, University College London, London, United Kingdom
⨯
Zoe Briggs,

Affiliation Medical Research Council Centre for Immune Regulation, School of Immunity and Infection, Institute of Biomedical Research, University of Birmingham Medical School, Birmingham, United Kingdom
⨯
Blagoje Soskic,

Affiliation UCL Institute of Immunity and Transplantation, Royal Free Campus, University College London, London, United Kingdom
⨯
Jennifer Baker,

Affiliation Medical Research Council Centre for Immune Regulation, School of Immunity and Infection, Institute of Biomedical Research, University of Birmingham Medical School, Birmingham, United Kingdom
⨯
Karim Raza ,

* E-mail: k.raza@bham.ac.uk

¶‡ These authors are joint senior authors on this work.

Affiliations Medical Research Council Centre for Immune Regulation, School of Immunity and Infection, Institute of Biomedical Research, University of Birmingham Medical School, Birmingham, United Kingdom, Department of Rheumatology, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, United Kingdom
⨯
David M. Sansom

¶‡ These authors are joint senior authors on this work.

Affiliation UCL Institute of Immunity and Transplantation, Royal Free Campus, University College London, London, United Kingdom
⨯

Vitamin D Antagonises the Suppressive Effect of Inflammatory Cytokines on CTLA-4 Expression and Regulatory Function

Louisa E. Jeffery,
Omar S. Qureshi,
David Gardner,
Tie Z. Hou,
Zoe Briggs,
Blagoje Soskic,
Jennifer Baker,
Karim Raza,
David M. Sansom

Published: July 2, 2015
https://doi.org/10.1371/journal.pone.0131539

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