Structural Basis for the Specificity of Human NUDT16 and Its Regulation by Inosine Monophosphate

Lionel Trésaugues; Thomas Lundbäck; Martin Welin; Susanne Flodin; Tomas Nyman; Camilla Silvander; Susanne Gräslund; Pär Nordlund

doi:10.1371/journal.pone.0131507

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Open Access

Peer-reviewed

Research Article

Structural Basis for the Specificity of Human NUDT16 and Its Regulation by Inosine Monophosphate

Lionel Trésaugues ,

* E-mail: Par.Nordlund@ki.se (PN); Lionel.Tresaugues@ki.se (LT)

Affiliations Structural Genomics Consortium, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden, Division of Biophysics, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
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Thomas Lundbäck,

Affiliation Chemical Biology Consortium Sweden, Science for Life Laboratories, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Solna, Sweden
⨯
Martin Welin,

Affiliation Structural Genomics Consortium, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
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Susanne Flodin,

Affiliation Structural Genomics Consortium, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
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Tomas Nyman,

Affiliation Structural Genomics Consortium, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
⨯
Camilla Silvander,

Current Address: Sprint Bioscience, Stockholm, Sweden

Affiliation Structural Genomics Consortium, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
⨯
Susanne Gräslund,

Affiliation Structural Genomics Consortium, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
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Pär Nordlund

* E-mail: Par.Nordlund@ki.se (PN); Lionel.Tresaugues@ki.se (LT)

Affiliations Structural Genomics Consortium, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden, Division of Biophysics, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden, Centre for Biomedical Structural Biology, School of Biological Sciences, Nanyang Technological University, Singapore, Singapore
⨯

Structural Basis for the Specificity of Human NUDT16 and Its Regulation by Inosine Monophosphate

Lionel Trésaugues,
Thomas Lundbäck,
Martin Welin,
Susanne Flodin,
Tomas Nyman,
Camilla Silvander,
Susanne Gräslund,
Pär Nordlund

Published: June 29, 2015
https://doi.org/10.1371/journal.pone.0131507

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Nucleotides
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Intrinsically disordered proteins
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Purines
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Monomers
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Phosphates
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Dimerization
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Dimers
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Crystal structure
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