Executioner Caspase-3 and 7 Deficiency Reduces Myocyte Number in the Developing Mouse Heart

Maria Cardona; Juan Antonio López; Anna Serafín; Anthony Rongvaux; Javier Inserte; David García-Dorado; Richard Flavell; Marta Llovera; Xavier Cañas; Jesús Vázquez; Daniel Sanchis

doi:10.1371/journal.pone.0131411

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Open Access

Peer-reviewed

Research Article

Executioner Caspase-3 and 7 Deficiency Reduces Myocyte Number in the Developing Mouse Heart

Maria Cardona,

Affiliation Departament de Ciències Mèdiques Bàsiques, Universitat de Lleida–IRBLLEIDA, Av. Rovira Roure, 80, Lleida, 25198, Spain
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Juan Antonio López,

Affiliation Centro Nacional de Investigaciones Cardiovasculares (CNIC), Melchor Fernández Almagro, 3, Madrid, 28029, Spain
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Anna Serafín,

Affiliation PCB-PRBB Animal Facility Alliance-Parc Científic de Barcelona, Baldiri Reixac, 4–6, Torre R, 4ª planta, Barcelona, 08028, Spain
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Anthony Rongvaux,

Affiliation Department of Immunobiology and Howard Hughes Medical Institute, Yale University School of Medicine, 300 Cedar St., New Haven, CT 06520, United States of America
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Javier Inserte,

Affiliation Institut de Recerca Hospital Universitari Vall d’Hebron—UAB, Passeig de la Vall d’Hebron, 119, Barcelona, 08035, Spain
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David García-Dorado,

Affiliation Institut de Recerca Hospital Universitari Vall d’Hebron—UAB, Passeig de la Vall d’Hebron, 119, Barcelona, 08035, Spain
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Richard Flavell,

Affiliation Department of Immunobiology and Howard Hughes Medical Institute, Yale University School of Medicine, 300 Cedar St., New Haven, CT 06520, United States of America
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Marta Llovera,

Affiliation Departament de Ciències Mèdiques Bàsiques, Universitat de Lleida–IRBLLEIDA, Av. Rovira Roure, 80, Lleida, 25198, Spain
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Xavier Cañas,

Current Address: Core Facilities–Institut de Recerca Hospital Universitari Vall d’Hebron. Passeig de la Vall d’Hebron, 119, Barcelona, 08035, Spain

Affiliation PCB-PRBB Animal Facility Alliance-Parc Científic de Barcelona, Baldiri Reixac, 4–6, Torre R, 4ª planta, Barcelona, 08028, Spain
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Jesús Vázquez,

Affiliation Centro Nacional de Investigaciones Cardiovasculares (CNIC), Melchor Fernández Almagro, 3, Madrid, 28029, Spain
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Daniel Sanchis

* E-mail: daniel.sanchis@cmb.udl.cat

Affiliation Departament de Ciències Mèdiques Bàsiques, Universitat de Lleida–IRBLLEIDA, Av. Rovira Roure, 80, Lleida, 25198, Spain
⨯

Executioner Caspase-3 and 7 Deficiency Reduces Myocyte Number in the Developing Mouse Heart

Maria Cardona,
Juan Antonio López,
Anna Serafín,
Anthony Rongvaux,
Javier Inserte,
David García-Dorado,
Richard Flavell,
Marta Llovera,
Xavier Cañas,
Jesús Vázquez

Published: June 29, 2015
https://doi.org/10.1371/journal.pone.0131411

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Heart
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Cardiomyocytes
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Gene expression
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Muscle cells
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Myocardium
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Genetically modified animals
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Cell cycle and cell division
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Gene regulation
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