Deep Sequencing Analysis of HBV Genotype Shift and Correlation with Antiviral Efficiency during Adefovir Dipivoxil Therapy

Yuwei Wang; Xuefeng Shan; Zhi Liang; Youlan Shan; Wenxiang Huang; Dazhi Zhang; Aizhong Zen; Xin Zhou; Yao Zhao; Xuyang Gong; Ge Xu; Xiuyu Zhang; Juan Chen; Ailong Huang

doi:10.1371/journal.pone.0131337

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Open Access

Peer-reviewed

Research Article

Deep Sequencing Analysis of HBV Genotype Shift and Correlation with Antiviral Efficiency during Adefovir Dipivoxil Therapy

Yuwei Wang ,

Contributed equally to this work with: Yuwei Wang, Xuefeng Shan, Zhi Liang

Affiliations Department of Laboratory Medicine, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, China, Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing, China
⨯
Xuefeng Shan ,

Contributed equally to this work with: Yuwei Wang, Xuefeng Shan, Zhi Liang

Affiliations Department of Pharmacy, the First Affiliated Hospital, Chongqing Medical University, Chongqing, China, Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing, China
⨯
Zhi Liang ,

Contributed equally to this work with: Yuwei Wang, Xuefeng Shan, Zhi Liang

Affiliation School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, China
⨯
Youlan Shan,

Affiliation Department of Infectious Diseases, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, China
⨯
Wenxiang Huang,

Affiliation Department of Infectious Diseases, the First Affiliated Hospital, Chongqing Medical University, Chongqing, China
⨯
Dazhi Zhang,

Affiliation Department of Infectious Diseases, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, China
⨯
Aizhong Zen,

Affiliation Department of Infectious Diseases, the First Affiliated Hospital, Chongqing Medical University, Chongqing, China
⨯
Xin Zhou,

Affiliation School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, China
⨯
Yao Zhao,

Affiliation Pediatric Research Institute, Children's Hospital of Chongqing Medical University, Chongqing, China
⨯
Xuyang Gong,

Affiliation Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing, China
⨯
Ge Xu,

Affiliation Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing, China
⨯
Xiuyu Zhang,

Affiliation Department of Infectious Diseases, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, China
⨯
Juan Chen ,

* E-mail: ahuang1964@163.com (ALH); yixin_xinyuan@163.com (JC)

Affiliation Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing, China
⨯
Ailong Huang

* E-mail: ahuang1964@163.com (ALH); yixin_xinyuan@163.com (JC)

Affiliation Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing, China
⨯

Deep Sequencing Analysis of HBV Genotype Shift and Correlation with Antiviral Efficiency during Adefovir Dipivoxil Therapy

Yuwei Wang,
Xuefeng Shan,
Zhi Liang,
Youlan Shan,
Wenxiang Huang,
Dazhi Zhang,
Aizhong Zen,
Xin Zhou,
Yao Zhao,
Xuyang Gong

Published: June 25, 2015
https://doi.org/10.1371/journal.pone.0131337

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