Targeted Overexpression of α-Synuclein by rAAV2/1 Vectors Induces Progressive Nigrostriatal Degeneration and Increases Vulnerability to MPTP in Mouse

Lian-Kun Song; Kai-Li Ma; Yu-He Yuan; Zheng Mu; Xiu-Yun Song; Fei Niu; Ning Han; Nai-Hong Chen

doi:10.1371/journal.pone.0131281

Loading metrics

Open Access

Peer-reviewed

Research Article

Targeted Overexpression of α-Synuclein by rAAV2/1 Vectors Induces Progressive Nigrostriatal Degeneration and Increases Vulnerability to MPTP in Mouse

Lian-Kun Song,

Affiliation State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China
⨯
Kai-Li Ma,

Affiliations State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China
⨯
Yu-He Yuan,

Affiliation State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China
⨯
Zheng Mu,

Affiliation State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China
⨯
Xiu-Yun Song,

Affiliation State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China
⨯
Fei Niu,

Affiliation State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China
⨯
Ning Han,

Affiliation State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China
⨯
Nai-Hong Chen

* E-mail: chennh@imm.ac.cn

Affiliations State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China, Hunan University of Chinese Medicine, Changsha, 410208, China
⨯

Targeted Overexpression of α-Synuclein by rAAV2/1 Vectors Induces Progressive Nigrostriatal Degeneration and Increases Vulnerability to MPTP in Mouse

Lian-Kun Song,
Kai-Li Ma,
Yu-He Yuan,
Zheng Mu,
Xiu-Yun Song,
Fei Niu,
Ning Han,
Nai-Hong Chen

Published: June 26, 2015
https://doi.org/10.1371/journal.pone.0131281

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Neurons
Is the Subject Area "Neurons" applicable to this article?

Thanks for your feedback.
Hyperexpression techniques
Is the Subject Area "Hyperexpression techniques" applicable to this article?

Thanks for your feedback.
Motor neurons
Is the Subject Area "Motor neurons" applicable to this article?

Thanks for your feedback.
Parkinson disease
Is the Subject Area "Parkinson disease" applicable to this article?

Thanks for your feedback.
Phosphorylation
Is the Subject Area "Phosphorylation" applicable to this article?

Thanks for your feedback.
Mice
Is the Subject Area "Mice" applicable to this article?

Thanks for your feedback.
Mouse models
Is the Subject Area "Mouse models" applicable to this article?

Thanks for your feedback.
Dopamine
Is the Subject Area "Dopamine" applicable to this article?

Thanks for your feedback.