Dual Fatty Acid Synthase and HER2 Signaling Blockade Shows Marked Antitumor Activity against Breast Cancer Models Resistant to Anti-HER2 Drugs

Adriana Blancafort; Ariadna Giró-Perafita; Glòria Oliveras; Sònia Palomeras; Carlos Turrado; Òscar Campuzano; Dolors Carrión-Salip; Anna Massaguer; Ramon Brugada; Marta Palafox; Jorge Gómez-Miragaya; Eva González-Suárez; Teresa Puig

doi:10.1371/journal.pone.0131241

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Open Access

Peer-reviewed

Research Article

Dual Fatty Acid Synthase and HER2 Signaling Blockade Shows Marked Antitumor Activity against Breast Cancer Models Resistant to Anti-HER2 Drugs

Adriana Blancafort,

Affiliation New Therapeutic Targets Lab (TargetsLab), Department of Medical Sciences, Faculty of Medicine, University of Girona, Girona, Spain
⨯
Ariadna Giró-Perafita,

Affiliation New Therapeutic Targets Lab (TargetsLab), Department of Medical Sciences, Faculty of Medicine, University of Girona, Girona, Spain
⨯
Glòria Oliveras,

Affiliations New Therapeutic Targets Lab (TargetsLab), Department of Medical Sciences, Faculty of Medicine, University of Girona, Girona, Spain, Catalan Institute of Oncology, Hospital Dr. Josep Trueta, Girona, Spain
⨯
Sònia Palomeras,

Affiliation New Therapeutic Targets Lab (TargetsLab), Department of Medical Sciences, Faculty of Medicine, University of Girona, Girona, Spain
⨯
Carlos Turrado,

Affiliation Química Orgánica I, Facultad de Ciencias Químicas, Universidad Complutense, Madrid, Spain
⨯
Òscar Campuzano,

Affiliation Cardiovascular Genetics Center, University of Girona-IDIBGi, Girona, Spain
⨯
Dolors Carrión-Salip,

Affiliation Biochemistry and Molecular Biology Unit, Department of Biology, University of Girona, Girona, Spain
⨯
Anna Massaguer,

Affiliation Biochemistry and Molecular Biology Unit, Department of Biology, University of Girona, Girona, Spain
⨯
Ramon Brugada,

Affiliation Cardiovascular Genetics Center, University of Girona-IDIBGi, Girona, Spain
⨯
Marta Palafox,

Affiliation Cancer Epigenetics and Biology Program (PEBC), Bellvitge Institute for Biomedical Research (IDIBELL), Hospitalet de Llobregat-Barcelona, Spain
⨯
Jorge Gómez-Miragaya,

Affiliation Cancer Epigenetics and Biology Program (PEBC), Bellvitge Institute for Biomedical Research (IDIBELL), Hospitalet de Llobregat-Barcelona, Spain
⨯
Eva González-Suárez,

Affiliation Cancer Epigenetics and Biology Program (PEBC), Bellvitge Institute for Biomedical Research (IDIBELL), Hospitalet de Llobregat-Barcelona, Spain
⨯
Teresa Puig

* E-mail: teresa.puig@udg.edu

Affiliation New Therapeutic Targets Lab (TargetsLab), Department of Medical Sciences, Faculty of Medicine, University of Girona, Girona, Spain
⨯

Dual Fatty Acid Synthase and HER2 Signaling Blockade Shows Marked Antitumor Activity against Breast Cancer Models Resistant to Anti-HER2 Drugs

Adriana Blancafort,
Ariadna Giró-Perafita,
Glòria Oliveras,
Sònia Palomeras,
Carlos Turrado,
Òscar Campuzano,
Dolors Carrión-Salip,
Anna Massaguer,
Ramon Brugada,
Marta Palafox

Published: June 24, 2015
https://doi.org/10.1371/journal.pone.0131241

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