Titanium Dioxide Nanoparticles Induce Endoplasmic Reticulum Stress-Mediated Autophagic Cell Death via Mitochondria-Associated Endoplasmic Reticulum Membrane Disruption in Normal Lung Cells

Kyeong-Nam Yu; Seung-Hee Chang; Soo Jin Park; Joohyun Lim; Jinkyu Lee; Tae-Jong Yoon; Jun-Sung Kim; Myung-Haing Cho

doi:10.1371/journal.pone.0131208

Loading metrics

Open Access

Peer-reviewed

Research Article

Titanium Dioxide Nanoparticles Induce Endoplasmic Reticulum Stress-Mediated Autophagic Cell Death via Mitochondria-Associated Endoplasmic Reticulum Membrane Disruption in Normal Lung Cells

Kyeong-Nam Yu,

Affiliation Laboratory of Toxicology, BK21 PLUS Program for Creative Veterinary Science Research, Research Institute for Veterinary Science and College of Veterinary Medicine, Seoul National University, Gwanak-gu, Seoul, Korea
⨯
Seung-Hee Chang,

Affiliation Laboratory of Toxicology, BK21 PLUS Program for Creative Veterinary Science Research, Research Institute for Veterinary Science and College of Veterinary Medicine, Seoul National University, Gwanak-gu, Seoul, Korea
⨯
Soo Jin Park,

Affiliation R&D Center, Biterials Co., Siksa-dong, Ilsandong-gu, Goyang-si, Gyeonggi-do, Korea, Korea
⨯
Joohyun Lim,

Affiliation Department of Chemistry, College of Natural Sciences, Gwanak-gu, Seoul National University, Seoul, Korea
⨯
Jinkyu Lee,

Affiliation Department of Chemistry, College of Natural Sciences, Gwanak-gu, Seoul National University, Seoul, Korea
⨯
Tae-Jong Yoon,

Affiliation Department of Applied Bioscience, College of Life Science, CHA University, Pocheon-shi, Gyeonggi-do, Korea
⨯
Jun-Sung Kim ,

* E-mail: lifeisgood@biterials.com (JSK); mchotox@snu.ac.kr (MHC)

Affiliation R&D Center, Biterials Co., Siksa-dong, Ilsandong-gu, Goyang-si, Gyeonggi-do, Korea, Korea
⨯
Myung-Haing Cho

* E-mail: lifeisgood@biterials.com (JSK); mchotox@snu.ac.kr (MHC)

Affiliations Laboratory of Toxicology, BK21 PLUS Program for Creative Veterinary Science Research, Research Institute for Veterinary Science and College of Veterinary Medicine, Seoul National University, Gwanak-gu, Seoul, Korea, Graduate Group of Tumor Biology, Seoul National University, Gwanak-gu, Seoul, Korea, Graduate School of Convergence Science and Technology, Seoul National University, Yeongtong-Gu, Suwon, Gyeonggi-Do, Korea, Advanced Institute of Convergence Technology, Seoul National University, Suwon, Gyeonggi-Do, Korea
⨯

Titanium Dioxide Nanoparticles Induce Endoplasmic Reticulum Stress-Mediated Autophagic Cell Death via Mitochondria-Associated Endoplasmic Reticulum Membrane Disruption in Normal Lung Cells

Kyeong-Nam Yu,
Seung-Hee Chang,
Soo Jin Park,
Joohyun Lim,
Jinkyu Lee,
Tae-Jong Yoon,
Jun-Sung Kim,
Myung-Haing Cho

Published: June 29, 2015
https://doi.org/10.1371/journal.pone.0131208

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Endoplasmic reticulum
Is the Subject Area "Endoplasmic reticulum" applicable to this article?

Thanks for your feedback.
Mitochondria
Is the Subject Area "Mitochondria" applicable to this article?

Thanks for your feedback.
Nanoparticles
Is the Subject Area "Nanoparticles" applicable to this article?

Thanks for your feedback.
Autophagic cell death
Is the Subject Area "Autophagic cell death" applicable to this article?

Thanks for your feedback.
Cell disruption
Is the Subject Area "Cell disruption" applicable to this article?

Thanks for your feedback.
Epithelial cells
Is the Subject Area "Epithelial cells" applicable to this article?

Thanks for your feedback.
Reactive oxygen species
Is the Subject Area "Reactive oxygen species" applicable to this article?

Thanks for your feedback.
Fluorescence imaging
Is the Subject Area "Fluorescence imaging" applicable to this article?

Thanks for your feedback.