High Fat Diet Enhances β-Site Cleavage of Amyloid Precursor Protein (APP) via Promoting β-Site APP Cleaving Enzyme 1/Adaptor Protein 2/Clathrin Complex Formation

Masato Maesako; Maiko Uemura; Yoshitaka Tashiro; Kazuki Sasaki; Kiwamu Watanabe; Yasuha Noda; Karin Ueda; Megumi Asada-Utsugi; Masakazu Kubota; Katsuya Okawa; Masafumi Ihara; Shun Shimohama; Kengo Uemura; Ayae Kinoshita

doi:10.1371/journal.pone.0131199

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Open Access

Peer-reviewed

Research Article

High Fat Diet Enhances β-Site Cleavage of Amyloid Precursor Protein (APP) via Promoting β-Site APP Cleaving Enzyme 1/Adaptor Protein 2/Clathrin Complex Formation

Masato Maesako,

Current address: Alzheimer’s Disease Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States of America

Affiliation Department of Human Health Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
⨯
Maiko Uemura,

Affiliation Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan
⨯
Yoshitaka Tashiro,

Affiliation SK project Medical Innovation Center, Kyoto University Graduate School of Medicine, Kyoto, Japan
⨯
Kazuki Sasaki,

Affiliation Department of Human Health Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
⨯
Kiwamu Watanabe,

Affiliation Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan
⨯
Yasuha Noda,

Affiliation Department of Human Health Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
⨯
Karin Ueda,

Affiliation Department of Human Health Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
⨯
Megumi Asada-Utsugi,

Affiliation Department of Human Health Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
⨯
Masakazu Kubota,

Affiliation Department of Human Health Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
⨯
Katsuya Okawa,

Affiliation Kyowa Hakko Kirin Co., Ltd, Shizuoka, Japan
⨯
Masafumi Ihara,

Affiliation Department of Neurology, National Cerebral and Cardiovascular Center, Osaka, Japan
⨯
Shun Shimohama,

Affiliation Department of Neurology, Sapporo Medical University, Sapporo, Japan
⨯
Kengo Uemura,

Affiliations Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan, Ishiki Hospital, Kagoshima, Japan
⨯
Ayae Kinoshita

* E-mail: kinoshita.ayae.6v@kyoto-u.ac.jp

Affiliation Department of Human Health Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
⨯

High Fat Diet Enhances β-Site Cleavage of Amyloid Precursor Protein (APP) via Promoting β-Site APP Cleaving Enzyme 1/Adaptor Protein 2/Clathrin Complex Formation

Masato Maesako,
Maiko Uemura,
Yoshitaka Tashiro,
Kazuki Sasaki,
Kiwamu Watanabe,
Yasuha Noda,
Karin Ueda,
Megumi Asada-Utsugi,
Masakazu Kubota,
Katsuya Okawa

Published: September 28, 2015
https://doi.org/10.1371/journal.pone.0131199

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