Angiopoietin Like Protein 2 (ANGPTL2) Promotes Adipose Tissue Macrophage and T lymphocyte Accumulation and Leads to Insulin Resistance

Yusuke Sasaki; Masayuki Ohta; Dhruv Desai; Jose-Luiz Figueiredo; Mary C. Whelan; Tomohiro Sugano; Masaki Yamabi; Wataru Yano; Tyler Faits; Katsumi Yabusaki; Hengmin Zhang; Andrew K. Mlynarchik; Keisuke Inoue; Ken Mizuno; Masanori Aikawa

doi:10.1371/journal.pone.0131176

Loading metrics

Open Access

Peer-reviewed

Research Article

Angiopoietin Like Protein 2 (ANGPTL2) Promotes Adipose Tissue Macrophage and T lymphocyte Accumulation and Leads to Insulin Resistance

Yusuke Sasaki,

Affiliations Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Tokyo New Drug Research Laboratories, Kowa Company, Ltd., Tokyo, Japan
⨯
Masayuki Ohta,

Affiliations Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Tokyo New Drug Research Laboratories, Kowa Company, Ltd., Tokyo, Japan
⨯
Dhruv Desai,

Affiliation Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Jose-Luiz Figueiredo,

Affiliation Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Mary C. Whelan,

Affiliation Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Tomohiro Sugano,

Affiliations Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Tokyo New Drug Research Laboratories, Kowa Company, Ltd., Tokyo, Japan
⨯
Masaki Yamabi,

Affiliations Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Tokyo New Drug Research Laboratories, Kowa Company, Ltd., Tokyo, Japan
⨯
Wataru Yano,

Affiliations Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Tokyo New Drug Research Laboratories, Kowa Company, Ltd., Tokyo, Japan
⨯
Tyler Faits,

Affiliation Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Katsumi Yabusaki,

Affiliations Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Tokyo New Drug Research Laboratories, Kowa Company, Ltd., Tokyo, Japan
⨯
Hengmin Zhang,

Affiliation Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Andrew K. Mlynarchik,

Affiliation Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Keisuke Inoue,

Affiliations Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Tokyo New Drug Research Laboratories, Kowa Company, Ltd., Tokyo, Japan
⨯
Ken Mizuno,

Affiliations Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Tokyo New Drug Research Laboratories, Kowa Company, Ltd., Tokyo, Japan
⨯
Masanori Aikawa

* E-mail: maikawa@rics.bwh.harvard.edu

Affiliation Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯

Angiopoietin Like Protein 2 (ANGPTL2) Promotes Adipose Tissue Macrophage and T lymphocyte Accumulation and Leads to Insulin Resistance

Yusuke Sasaki,
Masayuki Ohta,
Dhruv Desai,
Jose-Luiz Figueiredo,
Mary C. Whelan,
Tomohiro Sugano,
Masaki Yamabi,
Wataru Yano,
Tyler Faits,
Katsumi Yabusaki

Published: July 1, 2015
https://doi.org/10.1371/journal.pone.0131176

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Adipose tissue
Is the Subject Area "Adipose tissue" applicable to this article?

Thanks for your feedback.
Macrophages
Is the Subject Area "Macrophages" applicable to this article?

Thanks for your feedback.
Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.
Insulin resistance
Is the Subject Area "Insulin resistance" applicable to this article?

Thanks for your feedback.
Adenoviruses
Is the Subject Area "Adenoviruses" applicable to this article?

Thanks for your feedback.
Inflammation
Is the Subject Area "Inflammation" applicable to this article?

Thanks for your feedback.
Insulin
Is the Subject Area "Insulin" applicable to this article?

Thanks for your feedback.
T cells
Is the Subject Area "T cells" applicable to this article?

Thanks for your feedback.