Structural and Functional Analysis of Human HtrA3 Protease and Its Subdomains

Przemyslaw Glaza; Jerzy Osipiuk; Tomasz Wenta; Dorota Zurawa-Janicka; Miroslaw Jarzab; Adam Lesner; Bogdan Banecki; Joanna Skorko-Glonek; Andrzej Joachimiak; Barbara Lipinska

doi:10.1371/journal.pone.0131142

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Open Access

Peer-reviewed

Research Article

Structural and Functional Analysis of Human HtrA3 Protease and Its Subdomains

Przemyslaw Glaza,

Affiliation Department of Biochemistry, Faculty of Biology, University of Gdansk, 80–308 Gdansk, Poland
⨯
Jerzy Osipiuk,

Affiliations Midwest Center for Structural Genomics, Argonne National Laboratory, Argonne, Illinois, IL 60439, United States of America, Structural Biology Center, Biosciences Division, Argonne National Laboratory, Argonne, Illinois, IL 60439, United States of America
⨯
Tomasz Wenta,

Affiliation Department of Biochemistry, Faculty of Biology, University of Gdansk, 80–308 Gdansk, Poland
⨯
Dorota Zurawa-Janicka,

Affiliation Department of Biochemistry, Faculty of Biology, University of Gdansk, 80–308 Gdansk, Poland
⨯
Miroslaw Jarzab,

Affiliation Department of Biochemistry, Faculty of Biology, University of Gdansk, 80–308 Gdansk, Poland
⨯
Adam Lesner,

Affiliation Department of Biochemistry, Faculty of Chemistry, University of Gdansk, 80–308 Gdansk, Poland
⨯
Bogdan Banecki,

Affiliation Department of Molecular and Cellular Biology, Intercollegiate Faculty of Biotechnology of the University of Gdansk and the Medical University of Gdansk, 80–822 Gdansk, Poland
⨯
Joanna Skorko-Glonek,

Affiliation Department of Biochemistry, Faculty of Biology, University of Gdansk, 80–308 Gdansk, Poland
⨯
Andrzej Joachimiak,

Affiliations Midwest Center for Structural Genomics, Argonne National Laboratory, Argonne, Illinois, IL 60439, United States of America, Structural Biology Center, Biosciences Division, Argonne National Laboratory, Argonne, Illinois, IL 60439, United States of America
⨯
Barbara Lipinska

* E-mail: barbara.lipinska@biol.ug.edu.pl

Affiliation Department of Biochemistry, Faculty of Biology, University of Gdansk, 80–308 Gdansk, Poland
⨯

Structural and Functional Analysis of Human HtrA3 Protease and Its Subdomains

Przemyslaw Glaza,
Jerzy Osipiuk,
Tomasz Wenta,
Dorota Zurawa-Janicka,
Miroslaw Jarzab,
Adam Lesner,
Bogdan Banecki,
Joanna Skorko-Glonek,
Andrzej Joachimiak,
Barbara Lipinska

Published: June 25, 2015
https://doi.org/10.1371/journal.pone.0131142

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Proteases
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Crystal structure
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Protein structure
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Monomers
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Cancer treatment
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Serine proteases
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Size-exclusion chromatography
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