Widely Used Herpes Simplex Virus 1 ICP0 Deletion Mutant Strain dl1403 and Its Derivative Viruses Do Not Express Glycoprotein C Due to a Secondary Mutation in the gC Gene

Cristina W. Cunha; Kathryne E. Taylor; Suzanne M. Pritchard; Mark G. Delboy; Tri Komala Sari; Hector C. Aguilar; Karen L. Mossman; Anthony V. Nicola

doi:10.1371/journal.pone.0131129

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Research Article

Widely Used Herpes Simplex Virus 1 ICP0 Deletion Mutant Strain dl1403 and Its Derivative Viruses Do Not Express Glycoprotein C Due to a Secondary Mutation in the gC Gene

Cristina W. Cunha ,

Contributed equally to this work with: Cristina W. Cunha, Kathryne E. Taylor

Affiliation Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, Washington, United States of America
⨯
Kathryne E. Taylor ,

Contributed equally to this work with: Cristina W. Cunha, Kathryne E. Taylor

Affiliation Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada
⨯
Suzanne M. Pritchard,

Affiliation Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, Washington, United States of America
⨯
Mark G. Delboy,

Affiliation Department of Microbiology and Immunology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, United States of America
⨯
Tri Komala Sari,

Affiliation Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, Washington, United States of America
⨯
Hector C. Aguilar,

Affiliations Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, Washington, United States of America, Paul G. Allen School for Global Animal Health, Washington State University, Pullman, Washington, United States of America
⨯
Karen L. Mossman ,

* E-mail: mossk@mcmaster.ca (KLM); nicola@vetmed.wsu.edu (AVN)

Affiliation Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada
⨯
Anthony V. Nicola

* E-mail: mossk@mcmaster.ca (KLM); nicola@vetmed.wsu.edu (AVN)

Affiliations Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, Washington, United States of America, Paul G. Allen School for Global Animal Health, Washington State University, Pullman, Washington, United States of America
⨯

Widely Used Herpes Simplex Virus 1 ICP0 Deletion Mutant Strain dl1403 and Its Derivative Viruses Do Not Express Glycoprotein C Due to a Secondary Mutation in the gC Gene

Cristina W. Cunha,
Kathryne E. Taylor,
Suzanne M. Pritchard,
Mark G. Delboy,
Tri Komala Sari,
Hector C. Aguilar,
Karen L. Mossman,
Anthony V. Nicola

Published: July 17, 2015
https://doi.org/10.1371/journal.pone.0131129

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