Effects of Integrating and Non-Integrating Reprogramming Methods on Copy Number Variation and Genomic Stability of Human Induced Pluripotent Stem Cells

Xiangjin Kang; Qian Yu; Yuling Huang; Bing Song; Yaoyong Chen; Xingcheng Gao; Wenyin He; Xiaofang Sun; Yong Fan

doi:10.1371/journal.pone.0131128

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Peer-reviewed

Research Article

Effects of Integrating and Non-Integrating Reprogramming Methods on Copy Number Variation and Genomic Stability of Human Induced Pluripotent Stem Cells

Xiangjin Kang ,

Contributed equally to this work with: Xiangjin Kang, Qian Yu

Affiliation Key Laboratory for Major Obstetric Diseases of Guangdong Province, Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China
⨯
Qian Yu ,

Contributed equally to this work with: Xiangjin Kang, Qian Yu

Affiliation Key Laboratory for Major Obstetric Diseases of Guangdong Province, Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China
⨯
Yuling Huang,

Affiliation Key Laboratory for Major Obstetric Diseases of Guangdong Province, Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China
⨯
Bing Song,

Affiliation Key Laboratory for Major Obstetric Diseases of Guangdong Province, Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China
⨯
Yaoyong Chen,

Affiliation Key Laboratory for Major Obstetric Diseases of Guangdong Province, Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China
⨯
Xingcheng Gao,

Affiliation Key Laboratory for Major Obstetric Diseases of Guangdong Province, Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China
⨯
Wenyin He ,

* E-mail: 31848346@qq.com (WH); xiaofangsun@hotmail.com (XS); yongfan011@gzhmu.edu.cn (YF)

Affiliation Key Laboratory for Major Obstetric Diseases of Guangdong Province, Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China
⨯
Xiaofang Sun ,

* E-mail: 31848346@qq.com (WH); xiaofangsun@hotmail.com (XS); yongfan011@gzhmu.edu.cn (YF)

Affiliation Key Laboratory for Major Obstetric Diseases of Guangdong Province, Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China
⨯
Yong Fan

* E-mail: 31848346@qq.com (WH); xiaofangsun@hotmail.com (XS); yongfan011@gzhmu.edu.cn (YF)

Affiliation Key Laboratory for Major Obstetric Diseases of Guangdong Province, Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China
⨯

Effects of Integrating and Non-Integrating Reprogramming Methods on Copy Number Variation and Genomic Stability of Human Induced Pluripotent Stem Cells

Xiangjin Kang,
Qian Yu,
Yuling Huang,
Bing Song,
Yaoyong Chen,
Xingcheng Gao,
Wenyin He,
Xiaofang Sun,
Yong Fan

Published: July 1, 2015
https://doi.org/10.1371/journal.pone.0131128

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