Novel Human Embryonic Stem Cell Regulators Identified by Conserved and Distinct CpG Island Methylation State

Steve Pells; Eirini Koutsouraki; Sofia Morfopoulou; Sara Valencia-Cadavid; Simon R. Tomlinson; Ravi Kalathur; Matthias E. Futschik; Paul A. De Sousa

doi:10.1371/journal.pone.0131102

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Peer-reviewed

Research Article

Novel Human Embryonic Stem Cell Regulators Identified by Conserved and Distinct CpG Island Methylation State

Steve Pells ,

* E-mail: paul.desousa@ed.ac.uk (PDS); steve.pells@ed.ac.uk (SP)

Affiliations MRC Centre for Regenerative Medicine, School of Clinical Studies, University of Edinburgh, Edinburgh, EH16 4SB, United Kingdom, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, EH16 4SB, United Kingdom
⨯
Eirini Koutsouraki,

Affiliation MRC Centre for Regenerative Medicine, School of Clinical Studies, University of Edinburgh, Edinburgh, EH16 4SB, United Kingdom
⨯
Sofia Morfopoulou,

Affiliation MRC Centre for Regenerative Medicine, School of Clinical Studies, University of Edinburgh, Edinburgh, EH16 4SB, United Kingdom
⨯
Sara Valencia-Cadavid,

Affiliation MRC Centre for Regenerative Medicine, School of Clinical Studies, University of Edinburgh, Edinburgh, EH16 4SB, United Kingdom
⨯
Simon R. Tomlinson,

Affiliation MRC Centre for Regenerative Medicine, School of Clinical Studies, University of Edinburgh, Edinburgh, EH16 4SB, United Kingdom
⨯
Ravi Kalathur,

Affiliation Centre for Molecular and Structural Biomedicine, University of Algarve, 8005–139, Faro, Portugal
⨯
Matthias E. Futschik,

Affiliation Centre for Molecular and Structural Biomedicine, University of Algarve, 8005–139, Faro, Portugal
⨯
Paul A. De Sousa

* E-mail: paul.desousa@ed.ac.uk (PDS); steve.pells@ed.ac.uk (SP)

Affiliations MRC Centre for Regenerative Medicine, School of Clinical Studies, University of Edinburgh, Edinburgh, EH16 4SB, United Kingdom, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, EH16 4SB, United Kingdom
⨯

Novel Human Embryonic Stem Cell Regulators Identified by Conserved and Distinct CpG Island Methylation State

Steve Pells,
Eirini Koutsouraki,
Sofia Morfopoulou,
Sara Valencia-Cadavid,
Simon R. Tomlinson,
Ravi Kalathur,
Matthias E. Futschik,
Paul A. De Sousa

Published: July 7, 2015
https://doi.org/10.1371/journal.pone.0131102

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DNA methylation
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Pluripotency
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Small interfering RNA
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Biomarkers
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Methylation
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Gene expression
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Epigenetics
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Transfection
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