Basal Autophagy and Feedback Activation of Akt Are Associated with Resistance to Metformin-Induced Inhibition of Hepatic Tumor Cell Growth

Hua Yang; Yuan-Fei Peng; Hong-Min Ni; Yuan Li; Ying-Hong Shi; Wen-Xing Ding; Jia Fan

doi:10.1371/journal.pone.0130953

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Open Access

Peer-reviewed

Research Article

Basal Autophagy and Feedback Activation of Akt Are Associated with Resistance to Metformin-Induced Inhibition of Hepatic Tumor Cell Growth

Hua Yang ,

Contributed equally to this work with: Hua Yang, Yuan-Fei Peng

Current address: Department of General Surgery, Shanghai Public Health Clinical Center, Fudan University, Shanghai, 200032, China

Affiliations Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, 200032, China, Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, Kansas, 66160, United States of America
⨯
Yuan-Fei Peng ,

Contributed equally to this work with: Hua Yang, Yuan-Fei Peng

Affiliation Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, 200032, China
⨯
Hong-Min Ni,

Affiliation Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, Kansas, 66160, United States of America
⨯
Yuan Li,

Affiliation Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, Kansas, 66160, United States of America
⨯
Ying-Hong Shi,

Affiliation Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, 200032, China
⨯
Wen-Xing Ding ,

* E-mail: wxding@kumc.edu (WXD); fan.jia@zs-hospital.sh.cn (JF)

Affiliation Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, Kansas, 66160, United States of America
⨯
Jia Fan

* E-mail: wxding@kumc.edu (WXD); fan.jia@zs-hospital.sh.cn (JF)

Affiliation Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, 200032, China
⨯

Basal Autophagy and Feedback Activation of Akt Are Associated with Resistance to Metformin-Induced Inhibition of Hepatic Tumor Cell Growth

Hua Yang,
Yuan-Fei Peng,
Hong-Min Ni,
Yuan Li,
Ying-Hong Shi,
Wen-Xing Ding,
Jia Fan

Published: June 25, 2015
https://doi.org/10.1371/journal.pone.0130953

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Cell growth
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Hepatocellular carcinoma
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