Peripheral Blood Mitochondrial DNA as a Biomarker of Cerebral Mitochondrial Dysfunction following Traumatic Brain Injury in a Porcine Model

Todd J. Kilbaugh; Maria Lvova; Michael Karlsson; Zhe Zhang; Jeremy Leipzig; Douglas C. Wallace; Susan S. Margulies

doi:10.1371/journal.pone.0130927

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Peer-reviewed

Research Article

Peripheral Blood Mitochondrial DNA as a Biomarker of Cerebral Mitochondrial Dysfunction following Traumatic Brain Injury in a Porcine Model

Todd J. Kilbaugh ,

* E-mail: kilbaugh@chop.edu

Affiliation Department of Anesthesiology and Critical Care Medicine, Children’s Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Maria Lvova,

Affiliation Center for Mitochondrial and Epigenomic Medicine, Department of Pathology and Laboratory Medicine, Children’s Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Michael Karlsson,

Affiliation Mitochondrial Medicine, Department of Clinical Sciences, Lund University, Lund, Sweden
⨯
Zhe Zhang,

Affiliation Center for Mitochondrial and Epigenomic Medicine, Department of Pathology and Laboratory Medicine, Children’s Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Jeremy Leipzig,

Affiliation Center for Mitochondrial and Epigenomic Medicine, Department of Pathology and Laboratory Medicine, Children’s Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Douglas C. Wallace,

Affiliation Center for Mitochondrial and Epigenomic Medicine, Department of Pathology and Laboratory Medicine, Children’s Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Susan S. Margulies

Affiliation Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯

Peripheral Blood Mitochondrial DNA as a Biomarker of Cerebral Mitochondrial Dysfunction following Traumatic Brain Injury in a Porcine Model

Todd J. Kilbaugh,
Maria Lvova,
Michael Karlsson,
Zhe Zhang,
Jeremy Leipzig,
Douglas C. Wallace,
Susan S. Margulies

Published: June 22, 2015
https://doi.org/10.1371/journal.pone.0130927

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