Cardioprotection Resulting from Glucagon-Like Peptide-1 Administration Involves Shifting Metabolic Substrate Utilization to Increase Energy Efficiency in the Rat Heart

Open Access

Peer-reviewed

Research Article

Karpagam Aravindhan,

Affiliation Heart Failure Discovery Performance Unit, Metabolic Pathways and Cardiovascular Therapeutic Area, GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America
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Weike Bao,

Affiliation Heart Failure Discovery Performance Unit, Metabolic Pathways and Cardiovascular Therapeutic Area, GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America
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Mark R. Harpel,

Affiliation Heart Failure Discovery Performance Unit, Metabolic Pathways and Cardiovascular Therapeutic Area, GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America
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Robert N. Willette,

Affiliation Heart Failure Discovery Performance Unit, Metabolic Pathways and Cardiovascular Therapeutic Area, GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America
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John J. Lepore,

Affiliation Heart Failure Discovery Performance Unit, Metabolic Pathways and Cardiovascular Therapeutic Area, GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America
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Beat M. Jucker

* E-mail: Beat.M.Jucker@gsk.com

Current address: Preclinical & Translational Imaging, Laboratory Animal Sciences, Platform Technology & Science, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America

Affiliation Heart Failure Discovery Performance Unit, Metabolic Pathways and Cardiovascular Therapeutic Area, GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America
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Glucose
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Oxidation
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Heart
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Glucose metabolism
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Insulin
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Carbohydrates
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Myocardium
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Cardiac ventricles
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