The Additive Inflammatory In Vivo and In Vitro Effects of IL-7 and TSLP in Arthritis Underscore the Therapeutic Rationale for Dual Blockade

Maarten R. Hillen; Sarita A. Y. Hartgring; Cynthia R. Willis; Timothy R. D. J. Radstake; Cornelis E. Hack; Floris P. J. G. Lafeber; Joel A. G van Roon

doi:10.1371/journal.pone.0130830

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Open Access

Peer-reviewed

Research Article

The Additive Inflammatory In Vivo and In Vitro Effects of IL-7 and TSLP in Arthritis Underscore the Therapeutic Rationale for Dual Blockade

Maarten R. Hillen,

Affiliations Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands, Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
⨯
Sarita A. Y. Hartgring,

Affiliations Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands, Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
⨯
Cynthia R. Willis,

Affiliation Inflammation Lab, Amgen Inc., Seattle, Washington, United States of America
⨯
Timothy R. D. J. Radstake,

Affiliations Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands, Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
⨯
Cornelis E. Hack,

Affiliations Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands, Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
⨯
Floris P. J. G. Lafeber,

Affiliation Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
⨯
Joel A. G van Roon

* E-mail: j.vanroon@umcutrecht.nl

Affiliations Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands, Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
⨯

The Additive Inflammatory In Vivo and In Vitro Effects of IL-7 and TSLP in Arthritis Underscore the Therapeutic Rationale for Dual Blockade

Maarten R. Hillen,
Sarita A. Y. Hartgring,
Cynthia R. Willis,
Timothy R. D. J. Radstake,
Cornelis E. Hack,
Floris P. J. G. Lafeber,
Joel A. G van Roon

Published: June 25, 2015
https://doi.org/10.1371/journal.pone.0130830

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