Recombinant Soluble Respiratory Syncytial Virus F Protein That Lacks Heptad Repeat B, Contains a GCN4 Trimerization Motif and Is Not Cleaved Displays Prefusion-Like Characteristics

• Ivy Widjaja ,

  Contributed equally to this work with: Ivy Widjaja, Alan Rigter

  Affiliations Virology Division, Department of Infectious Diseases & Immunology, Faculty of Veterinary Medicine, Utrecht University, 3894 CL, Utrecht, The Netherlands, Mucosis B.V., Meditech Center, L.J. Zielstraweg 1, 9713 GX Groningen, The Netherlands

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• Alan Rigter †,

  Contributed equally to this work with: Ivy Widjaja, Alan Rigter

  † Deceased.

  Affiliations Virology Division, Department of Infectious Diseases & Immunology, Faculty of Veterinary Medicine, Utrecht University, 3894 CL, Utrecht, The Netherlands, Mucosis B.V., Meditech Center, L.J. Zielstraweg 1, 9713 GX Groningen, The Netherlands

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• Shamir Jacobino,

  Affiliation Department of Immunology, University Medical Center Utrecht, 3508 AB, Utrecht, The Netherlands

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• Frank J. M. van Kuppeveld,

  Affiliation Virology Division, Department of Infectious Diseases & Immunology, Faculty of Veterinary Medicine, Utrecht University, 3894 CL, Utrecht, The Netherlands

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• Kees Leenhouts,

  Affiliation Mucosis B.V., Meditech Center, L.J. Zielstraweg 1, 9713 GX Groningen, The Netherlands

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• Concepción Palomo,

  Affiliation Centro Nacional de Microbiología and CIBERES, Instituto de Salud Carlos III, Majadahonda, 28220, Madrid, Spain

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• Jose A. Melero,

  Affiliation Centro Nacional de Microbiología and CIBERES, Instituto de Salud Carlos III, Majadahonda, 28220, Madrid, Spain

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• Jeanette H. W. Leusen,

  Affiliation Department of Immunology, University Medical Center Utrecht, 3508 AB, Utrecht, The Netherlands

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• Bert Jan Haijema,

  Affiliation Mucosis B.V., Meditech Center, L.J. Zielstraweg 1, 9713 GX Groningen, The Netherlands

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• Peter J. M. Rottier,

  Affiliation Virology Division, Department of Infectious Diseases & Immunology, Faculty of Veterinary Medicine, Utrecht University, 3894 CL, Utrecht, The Netherlands

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• Cornelis A. M. de Haan

  * E-mail: c.a.m.dehaan@uu.nl

  Affiliation Virology Division, Department of Infectious Diseases & Immunology, Faculty of Veterinary Medicine, Utrecht University, 3894 CL, Utrecht, The Netherlands

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