Development of a Drug-Response Modeling Framework to Identify Cell Line Derived Translational Biomarkers That Can Predict Treatment Outcome to Erlotinib or Sorafenib

Bin Li; Hyunjin Shin; Georgy Gulbekyan; Olga Pustovalova; Yuri Nikolsky; Andrew Hope; Marina Bessarabova; Matthew Schu; Elona Kolpakova-Hart; David Merberg; Andrew Dorner; William L. Trepicchio

doi:10.1371/journal.pone.0130700

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Open Access

Peer-reviewed

Research Article

Development of a Drug-Response Modeling Framework to Identify Cell Line Derived Translational Biomarkers That Can Predict Treatment Outcome to Erlotinib or Sorafenib

Bin Li,

Affiliation Department of Translational Medicine, Takeda Pharmaceuticals International Co., 35 Landsdowne St., Cambridge, Massachusetts, 02139, United States of America
⨯
Hyunjin Shin,

Affiliation Department of Translational Medicine, Takeda Pharmaceuticals International Co., 35 Landsdowne St., Cambridge, Massachusetts, 02139, United States of America
⨯
Georgy Gulbekyan,

Affiliation Thomson Reuters, 777 E. Eisenhower Parkway, Ann Arbor, Michigan, 48108, United States of America
⨯
Olga Pustovalova,

Affiliation Thomson Reuters, 777 E. Eisenhower Parkway, Ann Arbor, Michigan, 48108, United States of America
⨯
Yuri Nikolsky,

Affiliation Thomson Reuters, 777 E. Eisenhower Parkway, Ann Arbor, Michigan, 48108, United States of America
⨯
Andrew Hope,

Affiliation Thomson Reuters, 777 E. Eisenhower Parkway, Ann Arbor, Michigan, 48108, United States of America
⨯
Marina Bessarabova,

Affiliation Thomson Reuters, 777 E. Eisenhower Parkway, Ann Arbor, Michigan, 48108, United States of America
⨯
Matthew Schu,

Affiliation Department of Translational Medicine, Takeda Pharmaceuticals International Co., 35 Landsdowne St., Cambridge, Massachusetts, 02139, United States of America
⨯
Elona Kolpakova-Hart,

Affiliation Thomson Reuters, 777 E. Eisenhower Parkway, Ann Arbor, Michigan, 48108, United States of America
⨯
David Merberg,

Affiliation Department of Translational Medicine, Takeda Pharmaceuticals International Co., 35 Landsdowne St., Cambridge, Massachusetts, 02139, United States of America
⨯
Andrew Dorner,

Affiliation Department of Translational Medicine, Takeda Pharmaceuticals International Co., 35 Landsdowne St., Cambridge, Massachusetts, 02139, United States of America
⨯
William L. Trepicchio

* E-mail: Bill.Trepicchio@takeda.com

Affiliation Department of Translational Medicine, Takeda Pharmaceuticals International Co., 35 Landsdowne St., Cambridge, Massachusetts, 02139, United States of America
⨯

Development of a Drug-Response Modeling Framework to Identify Cell Line Derived Translational Biomarkers That Can Predict Treatment Outcome to Erlotinib or Sorafenib

Bin Li,
Hyunjin Shin,
Georgy Gulbekyan,
Olga Pustovalova,
Yuri Nikolsky,
Andrew Hope,
Marina Bessarabova,
Matthew Schu,
Elona Kolpakova-Hart,
David Merberg

Published: June 24, 2015
https://doi.org/10.1371/journal.pone.0130700

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