Genetic Analysis of T Cell Lymphomas in Carbon Ion-Irradiated Mice Reveals Frequent Interstitial Chromosome Deletions: Implications for Second Cancer Induction in Normal Tissues during Carbon Ion Radiotherapy

Benjamin J. Blyth; Shizuko Kakinuma; Masaaki Sunaoshi; Yoshiko Amasaki; Shinobu Hirano-Sakairi; Kanae Ogawa; Ayana Shirakami; Yi Shang; Chizuru Tsuruoka; Mayumi Nishimura; Yoshiya Shimada

doi:10.1371/journal.pone.0130666

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Open Access

Peer-reviewed

Research Article

Genetic Analysis of T Cell Lymphomas in Carbon Ion-Irradiated Mice Reveals Frequent Interstitial Chromosome Deletions: Implications for Second Cancer Induction in Normal Tissues during Carbon Ion Radiotherapy

Benjamin J. Blyth,

Affiliation Radiobiology for Children’s Health Program, Research Center for Radiation Protection, National Institute of Radiological Sciences, Chiba, Japan
⨯
Shizuko Kakinuma,

Affiliation Radiobiology for Children’s Health Program, Research Center for Radiation Protection, National Institute of Radiological Sciences, Chiba, Japan
⨯
Masaaki Sunaoshi,

Affiliation Radiobiology for Children’s Health Program, Research Center for Radiation Protection, National Institute of Radiological Sciences, Chiba, Japan
⨯
Yoshiko Amasaki,

Affiliation Radiobiology for Children’s Health Program, Research Center for Radiation Protection, National Institute of Radiological Sciences, Chiba, Japan
⨯
Shinobu Hirano-Sakairi,

Affiliation Radiobiology for Children’s Health Program, Research Center for Radiation Protection, National Institute of Radiological Sciences, Chiba, Japan
⨯
Kanae Ogawa,

Affiliation Radiobiology for Children’s Health Program, Research Center for Radiation Protection, National Institute of Radiological Sciences, Chiba, Japan
⨯
Ayana Shirakami,

Affiliation Radiobiology for Children’s Health Program, Research Center for Radiation Protection, National Institute of Radiological Sciences, Chiba, Japan
⨯
Yi Shang,

Affiliation Radiobiology for Children’s Health Program, Research Center for Radiation Protection, National Institute of Radiological Sciences, Chiba, Japan
⨯
Chizuru Tsuruoka,

Affiliation Radiobiology for Children’s Health Program, Research Center for Radiation Protection, National Institute of Radiological Sciences, Chiba, Japan
⨯
Mayumi Nishimura,

Affiliation Radiobiology for Children’s Health Program, Research Center for Radiation Protection, National Institute of Radiological Sciences, Chiba, Japan
⨯
Yoshiya Shimada

* E-mail: y_shimad@nirs.go.jp

Affiliation Radiobiology for Children’s Health Program, Research Center for Radiation Protection, National Institute of Radiological Sciences, Chiba, Japan
⨯

Genetic Analysis of T Cell Lymphomas in Carbon Ion-Irradiated Mice Reveals Frequent Interstitial Chromosome Deletions: Implications for Second Cancer Induction in Normal Tissues during Carbon Ion Radiotherapy

Benjamin J. Blyth,
Shizuko Kakinuma,
Masaaki Sunaoshi,
Yoshiko Amasaki,
Shinobu Hirano-Sakairi,
Kanae Ogawa,
Ayana Shirakami,
Yi Shang,
Chizuru Tsuruoka,
Mayumi Nishimura

Published: June 30, 2015
https://doi.org/10.1371/journal.pone.0130666

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Cancers and neoplasms
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Chromosomal deletions
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Deletion mutation
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Radiation therapy
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Frameshift mutation
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Insertion mutation
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