Multi-Stage Tuberculosis Subunit Vaccine Candidate LT69 Provides High Protection against Mycobacterium tuberculosis Infection in Mice

Hongxia Niu; Jinxiu Peng; Chunxiang Bai; Xun Liu; Lina Hu; Yanping Luo; Bingxiang Wang; Ying Zhang; Jianzhu Chen; Hongjuan Yu; Qiaoyang Xian; Bingdong Zhu

doi:10.1371/journal.pone.0130641

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Open Access

Peer-reviewed

Research Article

Multi-Stage Tuberculosis Subunit Vaccine Candidate LT69 Provides High Protection against Mycobacterium tuberculosis Infection in Mice

Hongxia Niu,

Affiliations Gansu Provincial Key Laboratory of Evidence Based Medicine and Clinical Translation & Lanzhou Center for Tuberculosis Research, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China, Institute of Pathogen Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China
⨯
Jinxiu Peng,

Affiliations Gansu Provincial Key Laboratory of Evidence Based Medicine and Clinical Translation & Lanzhou Center for Tuberculosis Research, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China, Institute of Pathogen Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China
⨯
Chunxiang Bai,

Affiliations Gansu Provincial Key Laboratory of Evidence Based Medicine and Clinical Translation & Lanzhou Center for Tuberculosis Research, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China, Institute of Pathogen Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China
⨯
Xun Liu,

Affiliations Gansu Provincial Key Laboratory of Evidence Based Medicine and Clinical Translation & Lanzhou Center for Tuberculosis Research, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China, Institute of Pathogen Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China
⨯
Lina Hu,

Affiliation Lanzhou Institute of Biological Products, Lanzhou, China
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Yanping Luo,

Affiliation Gansu Provincial Key Laboratory of Evidence Based Medicine and Clinical Translation & Lanzhou Center for Tuberculosis Research, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China
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Bingxiang Wang,

Affiliation Lanzhou Institute of Biological Products, Lanzhou, China
⨯
Ying Zhang,

Affiliation Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University，Baltimore, Maryland, United States of America
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Jianzhu Chen,

Affiliation Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
⨯
Hongjuan Yu,

Affiliation Gansu Provincial Key Laboratory of Evidence Based Medicine and Clinical Translation & Lanzhou Center for Tuberculosis Research, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China
⨯
Qiaoyang Xian,

Affiliation ABSL-3 Lab, Wuhan University, Wuhan, China
⨯
Bingdong Zhu

* E-mail: bdzhu@lzu.edu.cn

Affiliations Gansu Provincial Key Laboratory of Evidence Based Medicine and Clinical Translation & Lanzhou Center for Tuberculosis Research, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China, Institute of Pathogen Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China
⨯

Multi-Stage Tuberculosis Subunit Vaccine Candidate LT69 Provides High Protection against Mycobacterium tuberculosis Infection in Mice

Hongxia Niu,
Jinxiu Peng,
Chunxiang Bai,
Xun Liu,
Lina Hu,
Yanping Luo,
Bingxiang Wang,
Ying Zhang,
Jianzhu Chen,
Hongjuan Yu

Published: June 22, 2015
https://doi.org/10.1371/journal.pone.0130641

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