Preclinical Potency and Biodistribution Studies of an AAV 5 Vector Expressing Human Interferon-β (ART-I02) for Local Treatment of Patients with Rheumatoid Arthritis

Caroline J. Aalbers; Lisette Bevaart; Scott Loiler; Karin de Cortie; J. Fraser Wright; Federico Mingozzi; Paul P. Tak; Margriet J. Vervoordeldonk

doi:10.1371/journal.pone.0130612

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Peer-reviewed

Research Article

Preclinical Potency and Biodistribution Studies of an AAV 5 Vector Expressing Human Interferon-β (ART-I02) for Local Treatment of Patients with Rheumatoid Arthritis

Caroline J. Aalbers ,

* E-mail: c.j.aalbers@amc.uva.nl

Affiliations Arthrogen B.V., Amsterdam, the Netherlands, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, the Netherlands
⨯
Lisette Bevaart,

Affiliations Arthrogen B.V., Amsterdam, the Netherlands, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, the Netherlands
⨯
Scott Loiler,

Current address: Center for Gene Therapy, The Research Institute, Nationwide Children’s Hospital, Columbus, Ohio, United States of America

Affiliations Arthrogen B.V., Amsterdam, the Netherlands, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, the Netherlands
⨯
Karin de Cortie,

Current address: TNO Triskelion, Zeist, the Netherlands

Affiliations Arthrogen B.V., Amsterdam, the Netherlands, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, the Netherlands
⨯
J. Fraser Wright,

Affiliations Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, Pennsylvania, United States of America, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Federico Mingozzi,

Affiliations University Pierre & Marie Curie, Paris, France, Genethon, Evry, France
⨯
Paul P. Tak,

Current address: GlaxoSmithKline, Stevenage, United Kingdom

Affiliations Arthrogen B.V., Amsterdam, the Netherlands, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, the Netherlands
⨯
Margriet J. Vervoordeldonk

Affiliations Arthrogen B.V., Amsterdam, the Netherlands, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, the Netherlands
⨯

Preclinical Potency and Biodistribution Studies of an AAV 5 Vector Expressing Human Interferon-β (ART-I02) for Local Treatment of Patients with Rheumatoid Arthritis

Caroline J. Aalbers,
Lisette Bevaart,
Scott Loiler,
Karin de Cortie,
J. Fraser Wright,
Federico Mingozzi,
Paul P. Tak,
Margriet J. Vervoordeldonk

Published: June 24, 2015
https://doi.org/10.1371/journal.pone.0130612

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