Clinical Significance of MLH1 Methylation and CpG Island Methylator Phenotype as Prognostic Markers in Patients with Gastric Cancer

Kunitoshi Shigeyasu; Takeshi Nagasaka; Yoshiko Mori; Naosuke Yokomichi; Takashi Kawai; Tomokazu Fuji; Keisuke Kimura; Yuzo Umeda; Shunsuke Kagawa; Ajay Goel; Toshiyoshi Fujiwara

doi:10.1371/journal.pone.0130409

Loading metrics

Open Access

Peer-reviewed

Research Article

Clinical Significance of MLH1 Methylation and CpG Island Methylator Phenotype as Prognostic Markers in Patients with Gastric Cancer

Kunitoshi Shigeyasu,

Affiliations Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan, Center for Epigenetics, Cancer Prevention and Cancer Genomics, Baylor Research Institute and Charles A Sammons Cancer Center, Baylor University Medical Center, Dallas, Texas, United States of America
⨯
Takeshi Nagasaka ,

* E-mail: takeshin@cc.okayama-u.ac.jp (TN); AjayG@BaylorHealth.edu (AG)

Affiliation Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan
⨯
Yoshiko Mori,

Affiliation Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan
⨯
Naosuke Yokomichi,

Affiliation Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan
⨯
Takashi Kawai,

Affiliation Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan
⨯
Tomokazu Fuji,

Affiliation Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan
⨯
Keisuke Kimura,

Affiliation Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan
⨯
Yuzo Umeda,

Affiliation Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan
⨯
Shunsuke Kagawa,

Affiliation Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan
⨯
Ajay Goel ,

* E-mail: takeshin@cc.okayama-u.ac.jp (TN); AjayG@BaylorHealth.edu (AG)

Affiliation Center for Epigenetics, Cancer Prevention and Cancer Genomics, Baylor Research Institute and Charles A Sammons Cancer Center, Baylor University Medical Center, Dallas, Texas, United States of America
⨯
Toshiyoshi Fujiwara

Affiliation Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan
⨯

Clinical Significance of MLH1 Methylation and CpG Island Methylator Phenotype as Prognostic Markers in Patients with Gastric Cancer

Kunitoshi Shigeyasu,
Takeshi Nagasaka,
Yoshiko Mori,
Naosuke Yokomichi,
Takashi Kawai,
Tomokazu Fuji,
Keisuke Kimura,
Yuzo Umeda,
Shunsuke Kagawa,
Ajay Goel

Published: June 29, 2015
https://doi.org/10.1371/journal.pone.0130409

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

DNA methylation
Is the Subject Area "DNA methylation" applicable to this article?

Thanks for your feedback.
Gastric cancer
Is the Subject Area "Gastric cancer" applicable to this article?

Thanks for your feedback.
Methylation
Is the Subject Area "Methylation" applicable to this article?

Thanks for your feedback.
Tumor suppressor genes
Is the Subject Area "Tumor suppressor genes" applicable to this article?

Thanks for your feedback.
Polymerase chain reaction
Is the Subject Area "Polymerase chain reaction" applicable to this article?

Thanks for your feedback.
Multivariate analysis
Is the Subject Area "Multivariate analysis" applicable to this article?

Thanks for your feedback.
Treatment guidelines
Is the Subject Area "Treatment guidelines" applicable to this article?

Thanks for your feedback.
Prognosis
Is the Subject Area "Prognosis" applicable to this article?

Thanks for your feedback.