Sphingosine-1-Phosphate Is a Novel Regulator of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activity

• Firhan A. Malik ,

  Contributed equally to this work with: Firhan A. Malik, Anja Meissner

  Affiliation Department of Physiology, University of Toronto, Medical Science Building, 1 King’s College Circle, Toronto, M5S 1A8 Canada

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• Anja Meissner ,

  Contributed equally to this work with: Firhan A. Malik, Anja Meissner

  Affiliations Department of Physiology, University of Toronto, Medical Science Building, 1 King’s College Circle, Toronto, M5S 1A8 Canada, Department of Brain Ischemia and Neurodegeneration, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Rosello 161, 6th floor, 08036 Barcelona, Spain

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• Illya Semenkov,

  Affiliation Department of Physiology, University of Toronto, Medical Science Building, 1 King’s College Circle, Toronto, M5S 1A8 Canada

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• Steven Molinski,

  Affiliations Department of Biochemistry, University of Toronto, Medical Science Building, 1 King’s College Circle, Toronto, M5S 1A8 Canada, Programme in Molecular Structure and Function in the Research Institute, The Hospital for Sick Children, 555 University Avenue, Toronto, MG5 1X8 Canada

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• Stan Pasyk,

  Affiliations Department of Biochemistry, University of Toronto, Medical Science Building, 1 King’s College Circle, Toronto, M5S 1A8 Canada, Programme in Molecular Structure and Function in the Research Institute, The Hospital for Sick Children, 555 University Avenue, Toronto, MG5 1X8 Canada

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• Saumel Ahmadi,

  Affiliations Department of Physiology, University of Toronto, Medical Science Building, 1 King’s College Circle, Toronto, M5S 1A8 Canada, Programme in Molecular Structure and Function in the Research Institute, The Hospital for Sick Children, 555 University Avenue, Toronto, MG5 1X8 Canada

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• Hai H. Bui,

  Affiliation Lilly Research Laboratories, Indianapolis, Indiana 46285, United States of America

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• Christine E. Bear,

  Affiliations Department of Physiology, University of Toronto, Medical Science Building, 1 King’s College Circle, Toronto, M5S 1A8 Canada, Department of Biochemistry, University of Toronto, Medical Science Building, 1 King’s College Circle, Toronto, M5S 1A8 Canada, Programme in Molecular Structure and Function in the Research Institute, The Hospital for Sick Children, 555 University Avenue, Toronto, MG5 1X8 Canada

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• Darcy Lidington ,

  ¶‡ These senior authors contributed equally to this work.

  Affiliations Department of Physiology, University of Toronto, Medical Science Building, 1 King’s College Circle, Toronto, M5S 1A8 Canada, Toronto Centre for Microvascular Medicine, University of Toronto and The Li Ka Shing Knowledge Institute at St. Michael’s Hospital, 209 Victoria Street, Toronto, M5B 1T8 Canada

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• Steffen-Sebastian Bolz

  * E-mail: sts.bolz@utoronto.ca

  ¶‡ These senior authors contributed equally to this work.

  Affiliations Department of Physiology, University of Toronto, Medical Science Building, 1 King’s College Circle, Toronto, M5S 1A8 Canada, Toronto Centre for Microvascular Medicine, University of Toronto and The Li Ka Shing Knowledge Institute at St. Michael’s Hospital, 209 Victoria Street, Toronto, M5B 1T8 Canada, Heart & Stroke / Richard Lewar Centre of Excellence for Cardiovascular Research, University of Toronto, 50 College Street, Toronto, M5S 3E2 Canada

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