miR-135b Promotes Cancer Progression by Targeting Transforming Growth Factor Beta Receptor II (TGFBR2) in Colorectal Cancer

Jialu Li; Hongwei Liang; Ming Bai; Tao Ning; Cheng Wang; Qian Fan; Yanbo Wang; Zheng Fu; Nan Wang; Rui Liu; Ke Zen; Chen-Yu Zhang; Xi Chen; Yi Ba

doi:10.1371/journal.pone.0130194

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Open Access

Peer-reviewed

Research Article

miR-135b Promotes Cancer Progression by Targeting Transforming Growth Factor Beta Receptor II (TGFBR2) in Colorectal Cancer

Jialu Li ,

Contributed equally to this work with: Jialu Li, Hongwei Liang, Ming Bai, Tao Ning

Affiliations Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tiyuanbei, Tianjin, 300060, China, Jiangsu Engineering Research Center for microRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, 210093, China
⨯
Hongwei Liang ,

Contributed equally to this work with: Jialu Li, Hongwei Liang, Ming Bai, Tao Ning

Affiliation Jiangsu Engineering Research Center for microRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, 210093, China
⨯
Ming Bai ,

Contributed equally to this work with: Jialu Li, Hongwei Liang, Ming Bai, Tao Ning

Affiliation Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tiyuanbei, Tianjin, 300060, China
⨯
Tao Ning ,

Contributed equally to this work with: Jialu Li, Hongwei Liang, Ming Bai, Tao Ning

Affiliation Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tiyuanbei, Tianjin, 300060, China
⨯
Cheng Wang,

Affiliations Jiangsu Engineering Research Center for microRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, 210093, China, Department of Clinical Laboratory, Jinling Hospital, Clinical School of Medical College, Nanjing University, Nanjing, China
⨯
Qian Fan,

Affiliations Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tiyuanbei, Tianjin, 300060, China, Jiangsu Engineering Research Center for microRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, 210093, China
⨯
Yanbo Wang,

Affiliation Jiangsu Engineering Research Center for microRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, 210093, China
⨯
Zheng Fu,

Affiliation Jiangsu Engineering Research Center for microRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, 210093, China
⨯
Nan Wang,

Affiliation Jiangsu Engineering Research Center for microRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, 210093, China
⨯
Rui Liu,

Affiliation Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tiyuanbei, Tianjin, 300060, China
⨯
Ke Zen,

Affiliation Jiangsu Engineering Research Center for microRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, 210093, China
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Chen-Yu Zhang ,

* E-mail: bayi@tjmuch.com (YB); xichen@nju.edu.cn (XC); cyzhang@nju.edu.cn (CYZ)

Affiliation Jiangsu Engineering Research Center for microRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, 210093, China
⨯
Xi Chen ,

* E-mail: bayi@tjmuch.com (YB); xichen@nju.edu.cn (XC); cyzhang@nju.edu.cn (CYZ)

Affiliation Jiangsu Engineering Research Center for microRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, 210093, China
⨯
Yi Ba

* E-mail: bayi@tjmuch.com (YB); xichen@nju.edu.cn (XC); cyzhang@nju.edu.cn (CYZ)

Affiliation Jiangsu Engineering Research Center for microRNA Biology and Biotechnology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, 210093, China
⨯

miR-135b Promotes Cancer Progression by Targeting Transforming Growth Factor Beta Receptor II (TGFBR2) in Colorectal Cancer

Jialu Li,
Hongwei Liang,
Ming Bai,
Tao Ning,
Cheng Wang,
Qian Fan,
Yanbo Wang,
Zheng Fu,
Nan Wang,
Rui Liu

Published: June 10, 2015
https://doi.org/10.1371/journal.pone.0130194

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Colorectal cancer
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TGF-beta signaling cascade
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MicroRNAs
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Transfection
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Small interfering RNA
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