SerpinB2 (PAI-2) Modulates Proteostasis via Binding Misfolded Proteins and Promotion of Cytoprotective Inclusion Formation

• Jodi A. Lee ,

  Contributed equally to this work with: Jodi A. Lee, Justin J. Yerbury

  Affiliations School of Biological Sciences, University of Wollongong, Wollongong, NSW, Australia, Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW, Australia

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• Justin J. Yerbury ,

  Contributed equally to this work with: Jodi A. Lee, Justin J. Yerbury

  Affiliations School of Biological Sciences, University of Wollongong, Wollongong, NSW, Australia, Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW, Australia

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• Natalie Farrawell,

  Affiliations School of Biological Sciences, University of Wollongong, Wollongong, NSW, Australia, Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW, Australia

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• Robert F. Shearer,

  Affiliations Kinghorn Cancer Centre and Cancer Research Program, Garvan Institute of Medical Research, Sydney, NSW, Australia, St Vincent’s Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia

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• Patrick Constantinescu,

  Affiliations School of Biological Sciences, University of Wollongong, Wollongong, NSW, Australia, Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW, Australia

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• Danny M. Hatters,

  Affiliation Department of Biochemistry and Molecular Biology and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Vic., Australia

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• Wayne A. Schroder,

  Affiliation QIMR Berghofer Medical Research Institute, Brisbane, Qld, Australia

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• Andreas Suhrbier,

  Affiliation QIMR Berghofer Medical Research Institute, Brisbane, Qld, Australia

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• Mark R. Wilson,

  Affiliations School of Biological Sciences, University of Wollongong, Wollongong, NSW, Australia, Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW, Australia

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• Darren N. Saunders ,

  * E-mail: d.saunders@garvan.org.au (DNS); mranson@uow.edu.au (MR)

  Affiliations Kinghorn Cancer Centre and Cancer Research Program, Garvan Institute of Medical Research, Sydney, NSW, Australia, St Vincent’s Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia

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• Marie Ranson

  * E-mail: d.saunders@garvan.org.au (DNS); mranson@uow.edu.au (MR)

  Affiliations School of Biological Sciences, University of Wollongong, Wollongong, NSW, Australia, Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW, Australia

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