Induction of Neuron-Specific Degradation of Coenzyme A Models Pantothenate Kinase-Associated Neurodegeneration by Reducing Motor Coordination in Mice

Stephanie A. Shumar; Paolo Fagone; Adolfo Alfonso-Pecchio; John T. Gray; Jerold E. Rehg; Suzanne Jackowski; Roberta Leonardi

doi:10.1371/journal.pone.0130013

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Research Article

Induction of Neuron-Specific Degradation of Coenzyme A Models Pantothenate Kinase-Associated Neurodegeneration by Reducing Motor Coordination in Mice

Stephanie A. Shumar,

Affiliation Department of Biochemistry, School of Medicine, West Virginia University, Morgantown, West Virginia, United States of America
⨯
Paolo Fagone,

Current address: Department of Biochemistry, School of Medicine, West Virginia University, Morgantown, West Virginia, United States of America

Affiliation Department of Hematology, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
⨯
Adolfo Alfonso-Pecchio,

Current address: UNC Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina at Chapel Hill, North Carolina, United States of America

Affiliation Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
⨯
John T. Gray,

Current address: Audentes Therapeutics, San Francisco, California, United States of America

Affiliation Department of Hematology, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
⨯
Jerold E. Rehg,

Affiliation Department of Pathology, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
⨯
Suzanne Jackowski,

Affiliation Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
⨯
Roberta Leonardi

* E-mail: roleonardi@hsc.wvu.edu

Affiliation Department of Biochemistry, School of Medicine, West Virginia University, Morgantown, West Virginia, United States of America
⨯

Induction of Neuron-Specific Degradation of Coenzyme A Models Pantothenate Kinase-Associated Neurodegeneration by Reducing Motor Coordination in Mice

Stephanie A. Shumar,
Paolo Fagone,
Adolfo Alfonso-Pecchio,
John T. Gray,
Jerold E. Rehg,
Suzanne Jackowski,
Roberta Leonardi

Published: June 8, 2015
https://doi.org/10.1371/journal.pone.0130013

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