Improving Detection of Arrhythmia Drug-Drug Interactions in Pharmacovigilance Data through the Implementation of Similarity-Based Modeling

Open Access

Peer-reviewed

Research Article

Santiago Vilar ,

* E-mail: sv2348@cumc.columbia.edu

Affiliations Department of Biomedical Informatics, Columbia University, New York, NY, United States of America, Department of Systems Biology, Columbia University, New York, NY, United States of America, Observational Health Data Sciences and Informatics (OHDSI), New York, NY, United States of America
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Tal Lorberbaum,

Affiliations Department of Biomedical Informatics, Columbia University, New York, NY, United States of America, Department of Systems Biology, Columbia University, New York, NY, United States of America
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George Hripcsak,

Affiliations Department of Biomedical Informatics, Columbia University, New York, NY, United States of America, Observational Health Data Sciences and Informatics (OHDSI), New York, NY, United States of America
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Nicholas P. Tatonetti

Affiliations Department of Biomedical Informatics, Columbia University, New York, NY, United States of America, Department of Systems Biology, Columbia University, New York, NY, United States of America, Observational Health Data Sciences and Informatics (OHDSI), New York, NY, United States of America, Department of Medicine, Columbia University, New York, NY, United States of America
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Drug interactions
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Drug safety
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Adverse reactions
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Drug-drug interactions
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Arrhythmia
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Linear discriminant analysis
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Data mining
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Principal component analysis
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