TAE226, a Bis-Anilino Pyrimidine Compound, Inhibits the EGFR-Mutant Kinase Including T790M Mutant to Show Anti-Tumor Effect on EGFR-Mutant Non-Small Cell Lung Cancer Cells

Hiroki Otani; Hiromasa Yamamoto; Munenori Takaoka; Masakiyo Sakaguchi; Junichi Soh; Masaru Jida; Tsuyoshi Ueno; Takafumi Kubo; Hiroaki Asano; Kazunori Tsukuda; Katsuyuki Kiura; Shinji Hatakeyama; Eiji Kawahara; Yoshio Naomoto; Shinichiro Miyoshi; Shinichi Toyooka

doi:10.1371/journal.pone.0129838

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Research Article

TAE226, a Bis-Anilino Pyrimidine Compound, Inhibits the EGFR-Mutant Kinase Including T790M Mutant to Show Anti-Tumor Effect on EGFR-Mutant Non-Small Cell Lung Cancer Cells

Hiroki Otani,

Affiliation Department of Thoracic, Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700–8558, Japan
⨯
Hiromasa Yamamoto,

Affiliation Department of Thoracic, Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700–8558, Japan
⨯
Munenori Takaoka,

Affiliation Department of General Surgery, Kawasaki Medical School, Okayama 700–8505, Japan
⨯
Masakiyo Sakaguchi,

Affiliation Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700–8558, Japan
⨯
Junichi Soh,

Affiliation Department of Thoracic, Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700–8558, Japan
⨯
Masaru Jida,

Affiliation Department of Thoracic, Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700–8558, Japan
⨯
Tsuyoshi Ueno,

Affiliation Department of Thoracic, Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700–8558, Japan
⨯
Takafumi Kubo,

Affiliation Department of Thoracic, Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700–8558, Japan
⨯
Hiroaki Asano,

Affiliation Department of Thoracic, Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700–8558, Japan
⨯
Kazunori Tsukuda,

Affiliation Department of Thoracic, Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700–8558, Japan
⨯
Katsuyuki Kiura,

Affiliation Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700–8558, Japan
⨯
Shinji Hatakeyama,

Affiliation Musculoskeletal Disease Area, Novartis Institutes for BioMedical Research Basel, Novartis Pharma AG, CH-4056, Basel, Switzerland
⨯
Eiji Kawahara,

Affiliation Department of Medical Science Liaison, Department of Oncology Development/Medical Affairs, Novartis Pharma K.K., Tokyo 106–0031, Japan
⨯
Yoshio Naomoto,

Affiliation Department of General Surgery, Kawasaki Medical School, Okayama 700–8505, Japan
⨯
Shinichiro Miyoshi,

Affiliation Department of Thoracic, Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700–8558, Japan
⨯
[ ... ],
Shinichi Toyooka

* E-mail: toyooka@md.okayama-u.ac.jp

Affiliations Department of Thoracic, Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700–8558, Japan, Department of Clinical Genomic Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700–8558, Japan
⨯
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TAE226, a Bis-Anilino Pyrimidine Compound, Inhibits the EGFR-Mutant Kinase Including T790M Mutant to Show Anti-Tumor Effect on EGFR-Mutant Non-Small Cell Lung Cancer Cells

Hiroki Otani,
Hiromasa Yamamoto,
Munenori Takaoka,
Masakiyo Sakaguchi,
Junichi Soh,
Masaru Jida,
Tsuyoshi Ueno,
Takafumi Kubo,
Hiroaki Asano,
Kazunori Tsukuda

Published: June 19, 2015
https://doi.org/10.1371/journal.pone.0129838

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