Salidroside Protects against Cadmium-Induced Hepatotoxicity in Rats via GJIC and MAPK Pathways

Hui Zou; Xuezhong Liu; Tao Han; Di Hu; Yi Wang; Yan Yuan; Jianhong Gu; Jianchun Bian; Jiaqiao Zhu; Zong-ping Liu

doi:10.1371/journal.pone.0129788

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Open Access

Peer-reviewed

Research Article

Salidroside Protects against Cadmium-Induced Hepatotoxicity in Rats via GJIC and MAPK Pathways

Hui Zou ,

Contributed equally to this work with: Hui Zou, Xuezhong Liu

Affiliation College of Veterinary Medicine, Yangzhou University, and Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, P.R. China
⨯
Xuezhong Liu ,

Contributed equally to this work with: Hui Zou, Xuezhong Liu

Affiliation College of Veterinary Medicine, Yangzhou University, and Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, P.R. China
⨯
Tao Han,

Affiliation College of Veterinary Medicine, Yangzhou University, and Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, P.R. China
⨯
Di Hu,

Affiliation College of Veterinary Medicine, Yangzhou University, and Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, P.R. China
⨯
Yi Wang,

Affiliation College of Veterinary Medicine, Yangzhou University, and Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, P.R. China
⨯
Yan Yuan,

Affiliation College of Veterinary Medicine, Yangzhou University, and Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, P.R. China
⨯
Jianhong Gu,

Affiliation College of Veterinary Medicine, Yangzhou University, and Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, P.R. China
⨯
Jianchun Bian,

Affiliation College of Veterinary Medicine, Yangzhou University, and Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, P.R. China
⨯
Jiaqiao Zhu ,

* E-mail: jqzhu1998@163.com (JZ); liuzongping@yzu.edu.cn (ZL)

Affiliation College of Veterinary Medicine, Yangzhou University, and Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, P.R. China
⨯
Zong-ping Liu

* E-mail: jqzhu1998@163.com (JZ); liuzongping@yzu.edu.cn (ZL)

Affiliation College of Veterinary Medicine, Yangzhou University, and Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, P.R. China
⨯

Salidroside Protects against Cadmium-Induced Hepatotoxicity in Rats via GJIC and MAPK Pathways

Hui Zou,
Xuezhong Liu,
Tao Han,
Di Hu,
Yi Wang,
Yan Yuan,
Jianhong Gu,
Jianchun Bian,
Jiaqiao Zhu,
Zong-ping Liu

Published: June 12, 2015
https://doi.org/10.1371/journal.pone.0129788

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MAPK signaling cascades
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Apoptosis
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Gap junctions
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Cytotoxicity
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Hepatocytes
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Gene expression
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Transmission electron microscopy
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