Modulation of PICALM Levels Perturbs Cellular Cholesterol Homeostasis

Jacob L. Mercer; Joseph P. Argus; Donna M. Crabtree; Melissa M. Keenan; Moses Q. Wilks; Jen-Tsan Ashley Chi; Steven J. Bensinger; Catherine P. Lavau; Daniel S. Wechsler

doi:10.1371/journal.pone.0129776

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Open Access

Peer-reviewed

Research Article

Modulation of PICALM Levels Perturbs Cellular Cholesterol Homeostasis

Jacob L. Mercer,

Affiliation Department of Pharmacology & Cancer Biology, Duke University, Durham, North Carolina, United States of America
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Joseph P. Argus,

Affiliation Department of Microbiology, Immunology and Molecular Genetics, Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California, United States of America
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Donna M. Crabtree,

Affiliation Department of Pediatrics, Division of Pediatric Hematology-Oncology, Duke University, Durham, North Carolina, United States of America
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Melissa M. Keenan,

Affiliations Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, United States of America, Center for Genomic and Computational Biology, Duke University, Durham, North Carolina, United States of America
⨯
Moses Q. Wilks,

Affiliation Department of Radiology, Center for Advanced Medical Imaging Sciences, Massachusetts General Hospital, Boston, Massachusetts, United States of America
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Jen-Tsan Ashley Chi,

Affiliations Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, United States of America, Center for Genomic and Computational Biology, Duke University, Durham, North Carolina, United States of America
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Steven J. Bensinger,

Affiliation Department of Microbiology, Immunology and Molecular Genetics, Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California, United States of America
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Catherine P. Lavau ,

Contributed equally to this work with: Catherine P. Lavau, Daniel S. Wechsler

Affiliation Department of Pediatrics, Division of Pediatric Hematology-Oncology, Duke University, Durham, North Carolina, United States of America
⨯
Daniel S. Wechsler

Contributed equally to this work with: Catherine P. Lavau, Daniel S. Wechsler

* E-mail: dan.wechsler@duke.edu

Affiliations Department of Pharmacology & Cancer Biology, Duke University, Durham, North Carolina, United States of America, Department of Pediatrics, Division of Pediatric Hematology-Oncology, Duke University, Durham, North Carolina, United States of America
⨯

Modulation of PICALM Levels Perturbs Cellular Cholesterol Homeostasis

Jacob L. Mercer,
Joseph P. Argus,
Donna M. Crabtree,
Melissa M. Keenan,
Moses Q. Wilks,
Jen-Tsan Ashley Chi,
Steven J. Bensinger,
Catherine P. Lavau,
Daniel S. Wechsler

Published: June 15, 2015
https://doi.org/10.1371/journal.pone.0129776

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