Role of Hypoxia-Induced Brain Derived Neurotrophic Factor in Human Pulmonary Artery Smooth Muscle

William Hartman; Martin Helan; Dan Smelter; Venkatachalem Sathish; Michael Thompson; Christina M. Pabelick; Bruce Johnson; Y. S. Prakash

doi:10.1371/journal.pone.0129489

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Open Access

Peer-reviewed

Research Article

Role of Hypoxia-Induced Brain Derived Neurotrophic Factor in Human Pulmonary Artery Smooth Muscle

William Hartman ,

* E-mail: hartman.william@mayo.edu

Affiliation Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota, 55905, United States of America
⨯
Martin Helan,

Affiliations International Clinical Research Center, Department of Cardiovascular Diseases, St. Anne's University Hospital, Brno, Czech Republic, Department of Anesthesiology and Intensive Care, St. Anne's University Hospital, Masaryk University, Brno, Czech Republic
⨯
Dan Smelter,

Affiliation Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota, 55905, United States of America
⨯
Venkatachalem Sathish,

Affiliations Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota, 55905, United States of America, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, 55905, United States of America
⨯
Michael Thompson,

Affiliation Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota, 55905, United States of America
⨯
Christina M. Pabelick,

Affiliations Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota, 55905, United States of America, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, 55905, United States of America
⨯
Bruce Johnson,

Affiliations Department of Internal Medicine, Division of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, 55905, United States of America, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, 55905, United States of America
⨯
Y. S. Prakash

Affiliations Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota, 55905, United States of America, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, 55905, United States of America
⨯

Role of Hypoxia-Induced Brain Derived Neurotrophic Factor in Human Pulmonary Artery Smooth Muscle

William Hartman,
Martin Helan,
Dan Smelter,
Venkatachalem Sathish,
Michael Thompson,
Christina M. Pabelick,
Bruce Johnson,
Y. S. Prakash

Published: July 20, 2015
https://doi.org/10.1371/journal.pone.0129489

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Medical hypoxia
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Smooth muscles
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Pulmonary arteries
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Apoptosis
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Enzyme-linked immunoassays
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Pulmonary vascular diseases
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MAPK signaling cascades
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