DNA Physical Properties and Nucleosome Positions Are Major Determinants of HIV-1 Integrase Selectivity

Monica Naughtin; Zofia Haftek-Terreau; Johan Xavier; Sam Meyer; Maud Silvain; Yan Jaszczyszyn; Nicolas Levy; Vincent Miele; Mohamed Salah Benleulmi; Marc Ruff; Vincent Parissi; Cédric Vaillant; Marc Lavigne

doi:10.1371/journal.pone.0129427

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Open Access

Peer-reviewed

Research Article

DNA Physical Properties and Nucleosome Positions Are Major Determinants of HIV-1 Integrase Selectivity

Monica Naughtin,

Current address: Institut Cochin, INSERM U 1016—CNRS UMR 8104, Paris, France

Affiliation Laboratoire Joliot-Curie, CNRS USR 3010, Ecole Normale Supérieure, Lyon, France
⨯
Zofia Haftek-Terreau,

Affiliation Laboratoire Joliot-Curie, CNRS USR 3010, Ecole Normale Supérieure, Lyon, France
⨯
Johan Xavier,

Affiliation Laboratoire Joliot-Curie, CNRS USR 3010, Ecole Normale Supérieure, Lyon, France
⨯
Sam Meyer,

Affiliation Université de Lyon, Microbiologie Adaptation et Pathogénie, INSA Lyon, CNRS UMR 5240, Lyon, France
⨯
Maud Silvain,

Affiliation Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS UMR9198, Université Paris-Sud, Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France
⨯
Yan Jaszczyszyn,

Affiliation Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS UMR9198, Université Paris-Sud, Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France
⨯
Nicolas Levy,

Affiliation Institut de Génétique et de Biologie Moléculaire et Cellulaire, Département de Biologie Structurale Intégrative, UDS, CNRS UMR 7104—INSERM U 964, Illkirch, France
⨯
Vincent Miele,

Affiliation Laboratoire de Biométrie et Biologie Evolutive, CNRS UMR 5558, Université Claude Bernard Lyon1, Lyon, France
⨯
Mohamed Salah Benleulmi,

Affiliation Laboratoire Microbiologie Fondamentale et Pathogénicité, CNRS UMR 5234, Université Victor Segalen Bordeaux 2, Bordeaux, France
⨯
Marc Ruff,

Affiliation Institut de Génétique et de Biologie Moléculaire et Cellulaire, Département de Biologie Structurale Intégrative, UDS, CNRS UMR 7104—INSERM U 964, Illkirch, France
⨯
Vincent Parissi,

Affiliation Laboratoire Microbiologie Fondamentale et Pathogénicité, CNRS UMR 5234, Université Victor Segalen Bordeaux 2, Bordeaux, France
⨯
Cédric Vaillant,

Affiliation Laboratoire du Physique, CNRS UMR 5672, Ecole Normale Supérieure, Lyon, France
⨯
Marc Lavigne

* E-mail: marc.lavigne@pasteur.fr

Current address: Institut Pasteur, Unité de Virologie Moléculaire et Vaccinologie, UMR 3569 CNRS, Paris, France

Affiliations Laboratoire Joliot-Curie, CNRS USR 3010, Ecole Normale Supérieure, Lyon, France, Institut Pasteur, Dpt de Virologie, UMR 3569 CNRS, Paris, France
⨯

DNA Physical Properties and Nucleosome Positions Are Major Determinants of HIV-1 Integrase Selectivity

Monica Naughtin,
Zofia Haftek-Terreau,
Johan Xavier,
Sam Meyer,
Maud Silvain,
Yan Jaszczyszyn,
Nicolas Levy,
Vincent Miele,
Mohamed Salah Benleulmi,
Marc Ruff

Published: June 15, 2015
https://doi.org/10.1371/journal.pone.0129427

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HIV-1
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