Cigarette Smoke-Induced Emphysema and Pulmonary Hypertension Can Be Prevented by Phosphodiesterase 4 and 5 Inhibition in Mice

Michael Seimetz; Nirmal Parajuli; Alexandra Pichl; Mariola Bednorz; Hossein Ardeschir Ghofrani; Ralph Theo Schermuly; Werner Seeger; Friedrich Grimminger; Norbert Weissmann

doi:10.1371/journal.pone.0129327

Loading metrics

Open Access

Peer-reviewed

Research Article

Cigarette Smoke-Induced Emphysema and Pulmonary Hypertension Can Be Prevented by Phosphodiesterase 4 and 5 Inhibition in Mice

Michael Seimetz ,

Contributed equally to this work with: Michael Seimetz, Nirmal Parajuli

Affiliation Universities of Giessen and Marburg Lung Center (UGMLC), Excellence Cluster Cardio-Pulmonary System (ECCPS), Member of the German Center for Lung Research (DZL), Giessen, Germany
⨯
Nirmal Parajuli ,

Contributed equally to this work with: Michael Seimetz, Nirmal Parajuli

Affiliation Universities of Giessen and Marburg Lung Center (UGMLC), Excellence Cluster Cardio-Pulmonary System (ECCPS), Member of the German Center for Lung Research (DZL), Giessen, Germany
⨯
Alexandra Pichl,

Affiliation Universities of Giessen and Marburg Lung Center (UGMLC), Excellence Cluster Cardio-Pulmonary System (ECCPS), Member of the German Center for Lung Research (DZL), Giessen, Germany
⨯
Mariola Bednorz,

Affiliation Universities of Giessen and Marburg Lung Center (UGMLC), Excellence Cluster Cardio-Pulmonary System (ECCPS), Member of the German Center for Lung Research (DZL), Giessen, Germany
⨯
Hossein Ardeschir Ghofrani,

Affiliation Universities of Giessen and Marburg Lung Center (UGMLC), Excellence Cluster Cardio-Pulmonary System (ECCPS), Member of the German Center for Lung Research (DZL), Giessen, Germany
⨯
Ralph Theo Schermuly,

Affiliation Universities of Giessen and Marburg Lung Center (UGMLC), Excellence Cluster Cardio-Pulmonary System (ECCPS), Member of the German Center for Lung Research (DZL), Giessen, Germany
⨯
Werner Seeger,

Affiliation Universities of Giessen and Marburg Lung Center (UGMLC), Excellence Cluster Cardio-Pulmonary System (ECCPS), Member of the German Center for Lung Research (DZL), Giessen, Germany
⨯
Friedrich Grimminger,

Affiliation Universities of Giessen and Marburg Lung Center (UGMLC), Excellence Cluster Cardio-Pulmonary System (ECCPS), Member of the German Center for Lung Research (DZL), Giessen, Germany
⨯
Norbert Weissmann

* E-mail: Norbert.Weissmann@innere.med.uni-giessen.de

Affiliation Universities of Giessen and Marburg Lung Center (UGMLC), Excellence Cluster Cardio-Pulmonary System (ECCPS), Member of the German Center for Lung Research (DZL), Giessen, Germany
⨯

Cigarette Smoke-Induced Emphysema and Pulmonary Hypertension Can Be Prevented by Phosphodiesterase 4 and 5 Inhibition in Mice

Michael Seimetz,
Nirmal Parajuli,
Alexandra Pichl,
Mariola Bednorz,
Hossein Ardeschir Ghofrani,
Ralph Theo Schermuly,
Werner Seeger,
Friedrich Grimminger,
Norbert Weissmann

Published: June 9, 2015
https://doi.org/10.1371/journal.pone.0129327

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Emphysema
Is the Subject Area "Emphysema" applicable to this article?

Thanks for your feedback.
Smoking habits
Is the Subject Area "Smoking habits" applicable to this article?

Thanks for your feedback.
Chronic obstructive pulmonary disease
Is the Subject Area "Chronic obstructive pulmonary disease" applicable to this article?

Thanks for your feedback.
Smoking related disorders
Is the Subject Area "Smoking related disorders" applicable to this article?

Thanks for your feedback.
Alveolar macrophages
Is the Subject Area "Alveolar macrophages" applicable to this article?

Thanks for your feedback.
Heart
Is the Subject Area "Heart" applicable to this article?

Thanks for your feedback.
Mouse models
Is the Subject Area "Mouse models" applicable to this article?

Thanks for your feedback.
Nitric oxide
Is the Subject Area "Nitric oxide" applicable to this article?

Thanks for your feedback.