Phosphatase Inhibitors Function as Novel, Broad Spectrum Botulinum Neurotoxin Antagonists in Mouse and Human Embryonic Stem Cell-Derived Motor Neuron-Based Assays

• Erkan Kiris ,

  * E-mail: sina.bavari.civ@mail.mil (SB); erkan.kiris@nih.gov (EK)

  Affiliations Geneva Foundation, Tacoma, WA, United States of America, Department of Molecular and Translational Sciences, US Army Medical Research Institute of Infectious Diseases, Frederick, MD, United States of America, Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute (NCI), Frederick, MD, United States of America

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• Jonathan E. Nuss,

  Affiliation Department of Molecular and Translational Sciences, US Army Medical Research Institute of Infectious Diseases, Frederick, MD, United States of America

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• Stephanie M. Stanford,

  Affiliation Division of Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, United States of America

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• Laura M. Wanner,

  Affiliation Department of Molecular and Translational Sciences, US Army Medical Research Institute of Infectious Diseases, Frederick, MD, United States of America

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• Lisa Cazares,

  Affiliation Department of Molecular and Translational Sciences, US Army Medical Research Institute of Infectious Diseases, Frederick, MD, United States of America

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• Michael F. Maestre,

  Affiliation Division of Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, United States of America

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• Hao T. Du,

  Affiliation Department of Molecular and Translational Sciences, US Army Medical Research Institute of Infectious Diseases, Frederick, MD, United States of America

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• Glenn Y. Gomba,

  Affiliation Department of Molecular and Translational Sciences, US Army Medical Research Institute of Infectious Diseases, Frederick, MD, United States of America

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• James C. Burnett,

  Affiliations Leidos Biomedical Research, Inc., Computational Drug Development Group (CDDG), NCI, Frederick, MD, United States of America, CDDG, Developmental Therapeutics Program, NCI, Frederick, MD, United States of America

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• Rick Gussio,

  Affiliation CDDG, Developmental Therapeutics Program, NCI, Frederick, MD, United States of America

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• Nunzio Bottini,

  Affiliation Division of Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, United States of America

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• Rekha G. Panchal,

  Affiliation Department of Molecular and Translational Sciences, US Army Medical Research Institute of Infectious Diseases, Frederick, MD, United States of America

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• Christopher D. Kane,

  Affiliations Department of Molecular and Translational Sciences, US Army Medical Research Institute of Infectious Diseases, Frederick, MD, United States of America, Henry M. Jackson Foundation, Bethesda, MD, United States of America, DoD Biotechnology High Performance Computing Software Applications Institute (BHSAI), Telemedicine and Advanced Technology Research Center (TATRC), US Army Medical Research and Materiel Command (USAMRMC), Frederick, MD, United States of America

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• Lino Tessarollo,

  Affiliation Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute (NCI), Frederick, MD, United States of America

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• Sina Bavari

  * E-mail: sina.bavari.civ@mail.mil (SB); erkan.kiris@nih.gov (EK)

  Affiliation Department of Molecular and Translational Sciences, US Army Medical Research Institute of Infectious Diseases, Frederick, MD, United States of America

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