Src Tyrosine Kinase Activation by 4-Hydroxynonenal Upregulates p38, ERK/AP-1 Signaling and COX-2 Expression in YPEN-1 Cells

Eun Ji Jang; Hyoung Oh Jeong; Daeui Park; Dae Hyun Kim; Yeon Ja Choi; Ki Wung Chung; Min Hi Park; Byung Pal Yu; Hae Young Chung

doi:10.1371/journal.pone.0129244

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Peer-reviewed

Research Article

Src Tyrosine Kinase Activation by 4-Hydroxynonenal Upregulates p38, ERK/AP-1 Signaling and COX-2 Expression in YPEN-1 Cells

Eun Ji Jang,

Affiliation Molecular Inflammation Research Center for Aging Intervention (MRCA), Department of Pharmacy, Pusan National University, Busan, Republic of Korea
⨯
Hyoung Oh Jeong,

Affiliations Molecular Inflammation Research Center for Aging Intervention (MRCA), Department of Pharmacy, Pusan National University, Busan, Republic of Korea, Interdisciplinary Research Program of Bioinformatics and Longevity Science, Pusan National University, Busan 609–735, Republic of Korea
⨯
Daeui Park,

Affiliations Molecular Inflammation Research Center for Aging Intervention (MRCA), Department of Pharmacy, Pusan National University, Busan, Republic of Korea, Interdisciplinary Research Program of Bioinformatics and Longevity Science, Pusan National University, Busan 609–735, Republic of Korea
⨯
Dae Hyun Kim,

Affiliation Molecular Inflammation Research Center for Aging Intervention (MRCA), Department of Pharmacy, Pusan National University, Busan, Republic of Korea
⨯
Yeon Ja Choi,

Affiliation Molecular Inflammation Research Center for Aging Intervention (MRCA), Department of Pharmacy, Pusan National University, Busan, Republic of Korea
⨯
Ki Wung Chung,

Affiliation Molecular Inflammation Research Center for Aging Intervention (MRCA), Department of Pharmacy, Pusan National University, Busan, Republic of Korea
⨯
Min Hi Park,

Affiliation Molecular Inflammation Research Center for Aging Intervention (MRCA), Department of Pharmacy, Pusan National University, Busan, Republic of Korea
⨯
Byung Pal Yu,

Affiliation Department of Physiology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229–3900, United States of America
⨯
Hae Young Chung

* E-mail: hyjung@pusan.ac.kr

Affiliation Molecular Inflammation Research Center for Aging Intervention (MRCA), Department of Pharmacy, Pusan National University, Busan, Republic of Korea
⨯

Src Tyrosine Kinase Activation by 4-Hydroxynonenal Upregulates p38, ERK/AP-1 Signaling and COX-2 Expression in YPEN-1 Cells

Eun Ji Jang,
Hyoung Oh Jeong,
Daeui Park,
Dae Hyun Kim,
Yeon Ja Choi,
Ki Wung Chung,
Min Hi Park,
Byung Pal Yu,
Hae Young Chung

Published: October 14, 2015
https://doi.org/10.1371/journal.pone.0129244

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