Host Subtraction, Filtering and Assembly Validations for Novel Viral Discovery Using Next Generation Sequencing Data

Gordon M. Daly; Richard M. Leggett; William Rowe; Samuel Stubbs; Maxim Wilkinson; Ricardo H. Ramirez-Gonzalez; Mario Caccamo; William Bernal; Jonathan L. Heeney

doi:10.1371/journal.pone.0129059

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Open Access

Peer-reviewed

Research Article

Host Subtraction, Filtering and Assembly Validations for Novel Viral Discovery Using Next Generation Sequencing Data

Gordon M. Daly ,

Contributed equally to this work with: Gordon M. Daly, Richard M. Leggett, Samuel Stubbs

Affiliation Lab of Viral Zoonotics, Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB30ES, United Kingdom
⨯
Richard M. Leggett ,

Contributed equally to this work with: Gordon M. Daly, Richard M. Leggett, Samuel Stubbs

Affiliation The Genome Analysis Centre (TGAC), Norwich Research Park, Norwich, NR47UH, United Kingdom
⨯
William Rowe,

Affiliation Lab of Viral Zoonotics, Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB30ES, United Kingdom
⨯
Samuel Stubbs ,

Contributed equally to this work with: Gordon M. Daly, Richard M. Leggett, Samuel Stubbs

Affiliation Lab of Viral Zoonotics, Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB30ES, United Kingdom
⨯
Maxim Wilkinson,

Affiliation Lab of Viral Zoonotics, Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB30ES, United Kingdom
⨯
Ricardo H. Ramirez-Gonzalez,

Affiliation The Genome Analysis Centre (TGAC), Norwich Research Park, Norwich, NR47UH, United Kingdom
⨯
Mario Caccamo,

Affiliation The Genome Analysis Centre (TGAC), Norwich Research Park, Norwich, NR47UH, United Kingdom
⨯
William Bernal,

Affiliation Institute of Liver Studies, King's College Hospital, Denmark Hill, London, SE59RS, United Kingdom
⨯
Jonathan L. Heeney

* E-mail: jlh66@cam.ac.uk

Affiliation Lab of Viral Zoonotics, Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB30ES, United Kingdom
⨯

Host Subtraction, Filtering and Assembly Validations for Novel Viral Discovery Using Next Generation Sequencing Data

Gordon M. Daly,
Richard M. Leggett,
William Rowe,
Samuel Stubbs,
Maxim Wilkinson,
Ricardo H. Ramirez-Gonzalez,
Mario Caccamo,
William Bernal,
Jonathan L. Heeney

Published: June 22, 2015
https://doi.org/10.1371/journal.pone.0129059

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Contig mapping
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Subtraction
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Genome complexity
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BLAST algorithm
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Next-generation sequencing
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Sequence alignment
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Hepatitis C virus
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