Bacterial Composition of the Human Upper Gastrointestinal Tract Microbiome Is Dynamic and Associated with Genomic Instability in a Barrett’s Esophagus Cohort

Alevtina Gall; Jutta Fero; Connor McCoy; Brian C. Claywell; Carissa A. Sanchez; Patricia L. Blount; Xiaohong Li; Thomas L. Vaughan; Frederick A. Matsen; Brian J. Reid; Nina R. Salama

doi:10.1371/journal.pone.0129055

Loading metrics

Open Access

Peer-reviewed

Research Article

Bacterial Composition of the Human Upper Gastrointestinal Tract Microbiome Is Dynamic and Associated with Genomic Instability in a Barrett’s Esophagus Cohort

Alevtina Gall,

Affiliations Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, Washington, United States of America, Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯
Jutta Fero,

Affiliation Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯
Connor McCoy,

Affiliations Divisions of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Program in Computational Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯
Brian C. Claywell,

Affiliations Divisions of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Program in Computational Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯
Carissa A. Sanchez,

Affiliation Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯
Patricia L. Blount,

Affiliations Divisions of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Department of Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America
⨯
Xiaohong Li,

Affiliations Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Divisions of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯
Thomas L. Vaughan,

Affiliations Divisions of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Department of Epidemiology, University of Washington, Seattle, Washington, United States of America
⨯
Frederick A. Matsen,

Affiliations Divisions of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Program in Computational Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯
Brian J. Reid,

Affiliations Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Divisions of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Department of Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America, Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America
⨯
Nina R. Salama

* E-mail: nsalama@fhcrc.org

Affiliations Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Department of Microbiology, University of Washington School of Medicine, Seattle, Washington, United States of America
⨯

Bacterial Composition of the Human Upper Gastrointestinal Tract Microbiome Is Dynamic and Associated with Genomic Instability in a Barrett’s Esophagus Cohort

Alevtina Gall,
Jutta Fero,
Connor McCoy,
Brian C. Claywell,
Carissa A. Sanchez,
Patricia L. Blount,
Xiaohong Li,
Thomas L. Vaughan,
Frederick A. Matsen,
Brian J. Reid

Published: June 15, 2015
https://doi.org/10.1371/journal.pone.0129055

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Barrett's esophagus
Is the Subject Area "Barrett's esophagus" applicable to this article?

Thanks for your feedback.
Stomach
Is the Subject Area "Stomach" applicable to this article?

Thanks for your feedback.
Biopsy
Is the Subject Area "Biopsy" applicable to this article?

Thanks for your feedback.
Helicobacter pylori
Is the Subject Area "Helicobacter pylori" applicable to this article?

Thanks for your feedback.
Streptococcus
Is the Subject Area "Streptococcus" applicable to this article?

Thanks for your feedback.
Prevotella
Is the Subject Area "Prevotella" applicable to this article?

Thanks for your feedback.
Esophagus
Is the Subject Area "Esophagus" applicable to this article?

Thanks for your feedback.
Microbiome
Is the Subject Area "Microbiome" applicable to this article?

Thanks for your feedback.