Antitumor Activity of a 5-Hydroxy-1H-Pyrrol-2-(5H)-One-Based Synthetic Small Molecule In Vitro and In Vivo

Yunyun Geng; Xiaojian Wang; Luo Yang; Haili Sun; Yongqiang Wang; Yue Zhao; Ruiping She; Mei-Xiang Wang; De-Xian Wang; Jun Tang

doi:10.1371/journal.pone.0128928

Loading metrics

Open Access

Peer-reviewed

Research Article

Antitumor Activity of a 5-Hydroxy-1H-Pyrrol-2-(5H)-One-Based Synthetic Small Molecule In Vitro and In Vivo

Yunyun Geng ,

Contributed equally to this work with: Yunyun Geng, Xiaojian Wang

Affiliation State Key Laboratory of Agrobiotechnology and College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China
⨯
Xiaojian Wang ,

Contributed equally to this work with: Yunyun Geng, Xiaojian Wang

Affiliation State Key Laboratory of Agrobiotechnology and College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China
⨯
Luo Yang,

Affiliation Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China
⨯
Haili Sun,

Affiliation State Key Laboratory of Agrobiotechnology and College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China
⨯
Yongqiang Wang,

Affiliation State Key Laboratory of Agrobiotechnology and College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China
⨯
Yue Zhao,

Affiliation State Key Laboratory of Agrobiotechnology and College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China
⨯
Ruiping She,

Affiliation State Key Laboratory of Agrobiotechnology and College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China
⨯
Mei-Xiang Wang,

Affiliation The Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, 100084, China
⨯
De-Xian Wang ,

* E-mail: dxwang@iccas.ac.cn (DXW); jtang@cau.edu.cn (JT)

Affiliation Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China
⨯
Jun Tang

* E-mail: dxwang@iccas.ac.cn (DXW); jtang@cau.edu.cn (JT)

Affiliation State Key Laboratory of Agrobiotechnology and College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China
⨯

Antitumor Activity of a 5-Hydroxy-1H-Pyrrol-2-(5H)-One-Based Synthetic Small Molecule In Vitro and In Vivo

Yunyun Geng,
Xiaojian Wang,
Luo Yang,
Haili Sun,
Yongqiang Wang,
Yue Zhao,
Ruiping She,
Mei-Xiang Wang,
De-Xian Wang,
Jun Tang

Published: June 4, 2015
https://doi.org/10.1371/journal.pone.0128928

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Apoptosis
Is the Subject Area "Apoptosis" applicable to this article?

Thanks for your feedback.
Synthesis phase
Is the Subject Area "Synthesis phase" applicable to this article?

Thanks for your feedback.
Cancer treatment
Is the Subject Area "Cancer treatment" applicable to this article?

Thanks for your feedback.
Lung and intrathoracic tumors
Is the Subject Area "Lung and intrathoracic tumors" applicable to this article?

Thanks for your feedback.
Cell cycle and cell division
Is the Subject Area "Cell cycle and cell division" applicable to this article?

Thanks for your feedback.
Malignant tumors
Is the Subject Area "Malignant tumors" applicable to this article?

Thanks for your feedback.
Cell staining
Is the Subject Area "Cell staining" applicable to this article?

Thanks for your feedback.
DNA damage
Is the Subject Area "DNA damage" applicable to this article?

Thanks for your feedback.