An Allergic Lung Microenvironment Suppresses Carbon Nanotube-Induced Inflammasome Activation via STAT6-Dependent Inhibition of Caspase-1

Kelly A. Shipkowski; Alexia J. Taylor; Elizabeth A. Thompson; Ellen E. Glista-Baker; Brian C. Sayers; Zachary J. Messenger; Rebecca N. Bauer; Ilona Jaspers; James C. Bonner

doi:10.1371/journal.pone.0128888

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Open Access

Peer-reviewed

Research Article

An Allergic Lung Microenvironment Suppresses Carbon Nanotube-Induced Inflammasome Activation via STAT6-Dependent Inhibition of Caspase-1

Kelly A. Shipkowski,

Affiliation Department of Biological Sciences, Environmental and Molecular Toxicology Program, North Carolina State University, Raleigh, North Carolina, United States of America
⨯
Alexia J. Taylor,

Affiliation Department of Biological Sciences, Environmental and Molecular Toxicology Program, North Carolina State University, Raleigh, North Carolina, United States of America
⨯
Elizabeth A. Thompson,

Affiliation Department of Biological Sciences, Environmental and Molecular Toxicology Program, North Carolina State University, Raleigh, North Carolina, United States of America
⨯
Ellen E. Glista-Baker,

Affiliation Department of Biological Sciences, Environmental and Molecular Toxicology Program, North Carolina State University, Raleigh, North Carolina, United States of America
⨯
Brian C. Sayers,

Affiliation Department of Biological Sciences, Environmental and Molecular Toxicology Program, North Carolina State University, Raleigh, North Carolina, United States of America
⨯
Zachary J. Messenger,

Affiliation Department of Biological Sciences, Environmental and Molecular Toxicology Program, North Carolina State University, Raleigh, North Carolina, United States of America
⨯
Rebecca N. Bauer,

Affiliation Center for Environmental Medicine, Asthma, and Lung Biology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, United States of America
⨯
Ilona Jaspers,

Affiliation Center for Environmental Medicine, Asthma, and Lung Biology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, United States of America
⨯
James C. Bonner

* E-mail: james_bonner@ncsu.edu

Affiliation Department of Biological Sciences, Environmental and Molecular Toxicology Program, North Carolina State University, Raleigh, North Carolina, United States of America
⨯

An Allergic Lung Microenvironment Suppresses Carbon Nanotube-Induced Inflammasome Activation via STAT6-Dependent Inhibition of Caspase-1

Kelly A. Shipkowski,
Alexia J. Taylor,
Elizabeth A. Thompson,
Ellen E. Glista-Baker,
Brian C. Sayers,
Zachary J. Messenger,
Rebecca N. Bauer,
Ilona Jaspers,
James C. Bonner

Published: June 19, 2015
https://doi.org/10.1371/journal.pone.0128888

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Inflammation
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Carbon nanotubes
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Inflammasomes
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