Ca2+/Calmodulin and Apo-Calmodulin Both Bind to and Enhance the Tyrosine Kinase Activity of c-Src

Open Access

Peer-reviewed

Research Article

Ca²⁺/Calmodulin and Apo-Calmodulin Both Bind to and Enhance the Tyrosine Kinase Activity of c-Src

Silviya R. Stateva ,

Contributed equally to this work with: Silviya R. Stateva, Valentina Salas

Affiliation Department of Cancer Biology, Instituto de Investigaciones Biomédicas, Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, c/ Arturo Duperier 4, E-28029, Madrid, Spain
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Valentina Salas ,

Contributed equally to this work with: Silviya R. Stateva, Valentina Salas

Affiliations Department of Cancer Biology, Instituto de Investigaciones Biomédicas, Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, c/ Arturo Duperier 4, E-28029, Madrid, Spain, Instituto de Biología Experimental, Facultad de Ciencias, Universidad Central de Venezuela, Caracas, Venezuela
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Estefanía Anguita,

Affiliation Department of Cancer Biology, Instituto de Investigaciones Biomédicas, Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, c/ Arturo Duperier 4, E-28029, Madrid, Spain
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Gustavo Benaim,

Affiliations Instituto de Biología Experimental, Facultad de Ciencias, Universidad Central de Venezuela, Caracas, Venezuela, Instituto de Estudios Avanzados (IDEA), Caracas, Venezuela
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Antonio Villalobo

* E-mail: antonio.villalobo@iib.uam.es

Affiliation Department of Cancer Biology, Instituto de Investigaciones Biomédicas, Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, c/ Arturo Duperier 4, E-28029, Madrid, Spain
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Phosphorylation
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Tyrosine kinases
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Cell membranes
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Protein kinases
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Western blot
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Recombination-based assay
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Co-immunoprecipitation
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Sequence motif analysis
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