Synthesis and Biological Evaluation of 3-Alkyl-1,5-Diaryl-1H-Pyrazoles as Rigid Analogues of Combretastatin A-4 with Potent Antiproliferative Activity

• Qile Xu,

  Affiliation Department Key Laboratory of Structure-Based Drug Design and Discovery Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China

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• Huan Qi,

  Affiliation Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, China

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• Maolin Sun,

  Affiliation Department Key Laboratory of Structure-Based Drug Design and Discovery Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China

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• Daiying Zuo,

  Affiliation Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, China

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• Xuewei Jiang,

  Affiliation Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, China

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• Zhiyong Wen,

  Affiliation Department Key Laboratory of Structure-Based Drug Design and Discovery Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China

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• Zhiwei Wang,

  Affiliation Department Key Laboratory of Structure-Based Drug Design and Discovery Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China

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• Yingliang Wu ,

  * E-mail: yingliang_1016@163.com (YW); zhangweige2000@sina.com (WZ)

  Affiliation Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, China

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• Weige Zhang

  * E-mail: yingliang_1016@163.com (YW); zhangweige2000@sina.com (WZ)

  Affiliation Department Key Laboratory of Structure-Based Drug Design and Discovery Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China

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