1,25 Dihydroxyvitamin D3 Inhibits TGFβ1-Mediated Primary Human Cardiac Myofibroblast Activation

Open Access

Peer-reviewed

Research Article

1,25 Dihydroxyvitamin D₃ Inhibits TGFβ₁-Mediated Primary Human Cardiac Myofibroblast Activation

Anna Meredith,

Affiliations Centre for Heart Lung Innovation, St. Paul’s Hospital, University of British Columbia, Vancouver, BC, Canada, Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada
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Seti Boroomand,

Affiliations Centre for Heart Lung Innovation, St. Paul’s Hospital, University of British Columbia, Vancouver, BC, Canada, Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada
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Jon Carthy,

Affiliation Ludwig Institute for Cancer Research, Uppsala, Sweden
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Zongshu Luo,

Affiliation Centre for Heart Lung Innovation, St. Paul’s Hospital, University of British Columbia, Vancouver, BC, Canada
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Bruce McManus

* E-mail: bruce.mcmanus@hli.ubc.ca

Affiliations Centre for Heart Lung Innovation, St. Paul’s Hospital, University of British Columbia, Vancouver, BC, Canada, Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada, PROOF Centre of Excellence, Vancouver, BC, Canada
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Vitamin D
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Fibroblasts
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Fibrosis
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Heart failure
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Collagens
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Muscle contraction
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Vitamin D deficiency
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Phosphorylation
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