Comparison of Gating Properties and Use-Dependent Block of Nav1.5 and Nav1.7 Channels by Anti-Arrhythmics Mexiletine and Lidocaine

Open Access

Peer-reviewed

Research Article

Comparison of Gating Properties and Use-Dependent Block of Na_v1.5 and Na_v1.7 Channels by Anti-Arrhythmics Mexiletine and Lidocaine

Ying Wang,

Affiliation Biomedical Research Institute, Shenzhen Peking University-Hong Kong University of Science and Technology Medical Center, Shenzhen 518036, China
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Jianxun Mi,

Affiliation Key Laboratory of Computational Intelligence, College of Computer Science and Technology, Chongqing University of Posts and Telecommunications, Chongqing 400065, China
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Ka Lu,

Affiliation Department of Molecular and Cellular Pharmacology, State Key Laboratory of Natural and Biomimetic Drugs, Peking University School of Pharmaceutical Sciences, Beijing 100191, China
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Yanxin Lu,

Affiliations Biomedical Research Institute, Shenzhen Peking University-Hong Kong University of Science and Technology Medical Center, Shenzhen 518036, China, Department of Molecular and Cellular Pharmacology, State Key Laboratory of Natural and Biomimetic Drugs, Peking University School of Pharmaceutical Sciences, Beijing 100191, China
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KeWei Wang

* E-mail: wangkw@hsc.pku.edu.cn

Affiliations Biomedical Research Institute, Shenzhen Peking University-Hong Kong University of Science and Technology Medical Center, Shenzhen 518036, China, Department of Molecular and Cellular Pharmacology, State Key Laboratory of Natural and Biomimetic Drugs, Peking University School of Pharmaceutical Sciences, Beijing 100191, China, Department of Pharmacology, Qingdao University School of Pharmacy, Qingdao 266021, China
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Sodium channels
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Voltage-gated sodium channels
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Curve fitting
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Ion channel gating
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Depolarization
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Membrane potential
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Arrhythmia
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Pain
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