A Defensin from the Model Beetle Tribolium castaneum Acts Synergistically with Telavancin and Daptomycin against Multidrug Resistant Staphylococcus aureus

Rajmohan Rajamuthiah; Elamparithi Jayamani; Annie L. Conery; Beth Burgwyn Fuchs; Wooseong Kim; Tatiana Johnston; Andreas Vilcinskas; Frederick M. Ausubel; Eleftherios Mylonakis

doi:10.1371/journal.pone.0128576

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Peer-reviewed

Research Article

A Defensin from the Model Beetle Tribolium castaneum Acts Synergistically with Telavancin and Daptomycin against Multidrug Resistant Staphylococcus aureus

Rajmohan Rajamuthiah,

Affiliations Division of Infectious Diseases, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI, 02903, United States of America, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, United States of America
⨯
Elamparithi Jayamani,

Affiliations Division of Infectious Diseases, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI, 02903, United States of America, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, United States of America
⨯
Annie L. Conery,

Affiliation Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, United States of America
⨯
Beth Burgwyn Fuchs,

Affiliation Division of Infectious Diseases, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI, 02903, United States of America
⨯
Wooseong Kim,

Affiliation Division of Infectious Diseases, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI, 02903, United States of America
⨯
Tatiana Johnston,

Affiliation Division of Infectious Diseases, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI, 02903, United States of America
⨯
Andreas Vilcinskas,

Affiliation Institute of Phytopathology and Applied Zoology, Justus-Liebig University, Heinrich-Buff-Ring 26–32, 35392, Giessen, Germany
⨯
Frederick M. Ausubel,

Affiliation Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, United States of America
⨯
Eleftherios Mylonakis

* E-mail: emylonakis@lifespan.org

Affiliations Division of Infectious Diseases, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI, 02903, United States of America, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, United States of America
⨯

A Defensin from the Model Beetle Tribolium castaneum Acts Synergistically with Telavancin and Daptomycin against Multidrug Resistant Staphylococcus aureus

Rajmohan Rajamuthiah,
Elamparithi Jayamani,
Annie L. Conery,
Beth Burgwyn Fuchs,
Wooseong Kim,
Tatiana Johnston,
Andreas Vilcinskas,
Frederick M. Ausubel,
Eleftherios Mylonakis

Published: June 10, 2015
https://doi.org/10.1371/journal.pone.0128576

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