Cell Kinetic Studies Fail to Identify Sequentially Proliferating Progenitors as the Major Source of Epithelial Renewal in the Adult Murine Prostate

Jean-Christophe Pignon; Chiara Grisanzio; Ingrid Carvo; Lillian Werner; Meredith Regan; E. Lynette Wilson; Sabina Signoretti

doi:10.1371/journal.pone.0128489

Loading metrics

Open Access

Peer-reviewed

Research Article

Cell Kinetic Studies Fail to Identify Sequentially Proliferating Progenitors as the Major Source of Epithelial Renewal in the Adult Murine Prostate

Jean-Christophe Pignon,

Affiliations Department of Pathology, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Chiara Grisanzio,

Affiliations Department of Pathology, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
⨯
Ingrid Carvo,

Affiliation Department of Pathology, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America
⨯
Lillian Werner,

Affiliations Harvard Medical School, Boston, Massachusetts, United States of America, Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
⨯
Meredith Regan,

Affiliations Harvard Medical School, Boston, Massachusetts, United States of America, Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
⨯
E. Lynette Wilson,

Affiliation Departments of Cell Biology and Urology, School of Medicine, New York University, New York, New York, United States of America
⨯
Sabina Signoretti

* E-mail: ssignoretti@partners.org

Affiliations Department of Pathology, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
⨯

Cell Kinetic Studies Fail to Identify Sequentially Proliferating Progenitors as the Major Source of Epithelial Renewal in the Adult Murine Prostate

Jean-Christophe Pignon,
Chiara Grisanzio,
Ingrid Carvo,
Lillian Werner,
Meredith Regan,
E. Lynette Wilson,
Sabina Signoretti

Published: May 29, 2015
https://doi.org/10.1371/journal.pone.0128489

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Prostate gland
Is the Subject Area "Prostate gland" applicable to this article?

Thanks for your feedback.
Epithelium
Is the Subject Area "Epithelium" applicable to this article?

Thanks for your feedback.
Epithelial cells
Is the Subject Area "Epithelial cells" applicable to this article?

Thanks for your feedback.
Androgens
Is the Subject Area "Androgens" applicable to this article?

Thanks for your feedback.
Thymidines
Is the Subject Area "Thymidines" applicable to this article?

Thanks for your feedback.
Basal cells
Is the Subject Area "Basal cells" applicable to this article?

Thanks for your feedback.
Cell cycle and cell division
Is the Subject Area "Cell cycle and cell division" applicable to this article?

Thanks for your feedback.
Stem cells
Is the Subject Area "Stem cells" applicable to this article?

Thanks for your feedback.