EETs Attenuate Ox-LDL-Induced LTB4 Production and Activity by Inhibiting p38 MAPK Phosphorylation and 5-LO/BLT1 Receptor Expression in Rat Pulmonary Arterial Endothelial Cells

Jun-xia Jiang; Shui-juan Zhang; Yao-kang Xiong; Yong-liang Jia; Yan-hong Sun; Xi-xi Lin; Hui-juan Shen; Qiang-min Xie; Xiao-feng Yan

doi:10.1371/journal.pone.0128278

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Open Access

Peer-reviewed

Research Article

EETs Attenuate Ox-LDL-Induced LTB₄ Production and Activity by Inhibiting p38 MAPK Phosphorylation and 5-LO/BLT1 Receptor Expression in Rat Pulmonary Arterial Endothelial Cells

Jun-xia Jiang ,

Contributed equally to this work with: Jun-xia Jiang, Shui-juan Zhang

Affiliation The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
⨯
Shui-juan Zhang ,

Contributed equally to this work with: Jun-xia Jiang, Shui-juan Zhang

Affiliation College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China
⨯
Yao-kang Xiong,

Affiliation College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China
⨯
Yong-liang Jia,

Affiliation Zhejiang Respiratory Drugs Research Laboratory of China FDA, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
⨯
Yan-hong Sun,

Affiliation Zhejiang Respiratory Drugs Research Laboratory of China FDA, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
⨯
Xi-xi Lin,

Affiliation Zhejiang Respiratory Drugs Research Laboratory of China FDA, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
⨯
Hui-juan Shen,

Affiliation The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
⨯
Qiang-min Xie ,

* E-mail: yanxiaofeng0804@sina.com (XFY); xieqm@zju.edu.cn (QMX)

Affiliation Zhejiang Respiratory Drugs Research Laboratory of China FDA, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
⨯
Xiao-feng Yan

* E-mail: yanxiaofeng0804@sina.com (XFY); xieqm@zju.edu.cn (QMX)

Affiliation The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
⨯

EETs Attenuate Ox-LDL-Induced LTB₄ Production and Activity by Inhibiting p38 MAPK Phosphorylation and 5-LO/BLT1 Receptor Expression in Rat Pulmonary Arterial Endothelial Cells

Jun-xia Jiang,
Shui-juan Zhang,
Yao-kang Xiong,
Yong-liang Jia,
Yan-hong Sun,
Xi-xi Lin,
Hui-juan Shen,
Qiang-min Xie,
Xiao-feng Yan

Published: June 2, 2015
https://doi.org/10.1371/journal.pone.0128278

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