High-Fat Diet Induces Hepatic Insulin Resistance and Impairment of Synaptic Plasticity

Zhigang Liu; Ishan Y. Patil; Tianyi Jiang; Harsh Sancheti; John P. Walsh; Bangyan L. Stiles; Fei Yin; Enrique Cadenas

doi:10.1371/journal.pone.0128274

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Peer-reviewed

Research Article

High-Fat Diet Induces Hepatic Insulin Resistance and Impairment of Synaptic Plasticity

Zhigang Liu,

Affiliations Pharmacology & Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, 90089, United States of America, College of Food Science and Engineering, Northwest A&F University, Yangling, China
⨯
Ishan Y. Patil,

Affiliation Pharmacology & Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, 90089, United States of America
⨯
Tianyi Jiang,

Affiliation Pharmacology & Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, 90089, United States of America
⨯
Harsh Sancheti,

Affiliation Pharmacology & Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, 90089, United States of America
⨯
John P. Walsh,

Affiliation Davis School of Gerontology and Program in Neuroscience, University of Southern California, Los Angeles, CA, 90089, United States of America
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Bangyan L. Stiles,

Affiliation Pharmacology & Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, 90089, United States of America
⨯
Fei Yin,

Affiliation Pharmacology & Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, 90089, United States of America
⨯
Enrique Cadenas

* E-mail: cadenas@usc.edu

Affiliation Pharmacology & Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, 90089, United States of America
⨯

High-Fat Diet Induces Hepatic Insulin Resistance and Impairment of Synaptic Plasticity

Zhigang Liu,
Ishan Y. Patil,
Tianyi Jiang,
Harsh Sancheti,
John P. Walsh,
Bangyan L. Stiles,
Fei Yin,
Enrique Cadenas

Published: May 29, 2015
https://doi.org/10.1371/journal.pone.0128274

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Insulin resistance
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Insulin
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Hepatocytes
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Insulin signaling
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Synaptic plasticity
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Inflammation
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Mouse models
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Obesity
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